Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials

被引：253
作者：
Caster, Joseph M. [1 ]
Patel, Artish N. [1 ]
Zhang, Tian [2 ]
Wang, Andrew [1 ]
机构：
[1] Univ North Carolina Chapel Hill, Dept Radiat Oncol, Chapel Hill, NC 27514 USA
[2] Duke Univ, Dept Med, Durham, NC USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2017年 / 9卷 / 01期
关键词：
CELL LUNG-CANCER; PHASE-III TRIAL; INCORPORATING MICELLAR NANOPARTICLE; ADVANCED SOLID TUMORS; COMPARING PACLITAXEL POLIGLUMEX; GYNECOLOGIC-ONCOLOGY-GROUP; LIPID-BASED PRODRUG; PS; PATIENTS; GENEXOL-PM; PSEUDOMONAS-AERUGINOSA;
D O I：
10.1002/wnan.1416
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Nanomedicine is a relatively new field that is rapidly evolving. Formulation of drugs on the nanoscale imparts many physical and biological advantages. Such advantages can in turn translate into improved therapeutic efficacy and reduced toxicity. While approximately 50 nanotherapeutics have already entered clinical practice, a greater number of drugs are undergoing clinical investigation for a variety of indications. This review aims to examine all the nanoformulations that are currently undergoing clinical investigation and their outlook for ultimate clinical translation. WIREs Nanomed Nanobiotechnol 2017, 9:e1416. doi: 10.1002/wnan.1416 For further resources related to this article, please visit the .
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