KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma

被引：14

作者：

Xu, Hui ^{[1
]}

Shao, Chuan ^{[1
,2
,3
]}

机构：

[1] Lihuili Hosp, Ningbo Med Ctr, Dept Pulm & Crit Care Med, 1111 Jiangnan Rd, Ningbo 315040, Zhejiang, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Special Procurement Ward, Suzhou, Jiangsu, Peoples R China

[3] Soochow Univ, Affiliated Hosp 1, Dept Gen Practice, Suzhou, Jiangsu, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2020年 / 13卷

关键词：

non-small cell lung cancer; adenocarcinoma; KIF5B-EGFR; EGFR-TKIs; next generation sequencing; CANCER; BEVACIZUMAB; GEFITINIB; 1ST-LINE; TRIAL;

D O I：

10.2147/OTT.S263994

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51, are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B (KIF5B)-EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients.

引用

页码：8317 / 8321

页数：5

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