Mitochondria in lung diseases

被引：74

作者：

Aravamudan, Bharathi ^{[1
,2
]}

Thompson, Michael A. ^{[1
,2
]}

Pabelick, Christina M. ^{[1
,2
]}

Prakash, Y. S. ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Anesthesiol Physiol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Biomed Engn, Rochester, MN 55905 USA

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2013年 / 7卷 / 06期

基金：

美国国家卫生研究院;

关键词：

airway; apoptosis; autophagy; fission; fusion; mitochondria; oxidative stress; proliferation; reactive oxygen species;

D O I：

10.1586/17476348.2013.834252

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering and cell fate determination. Regulation of their morphology and diverse activities beyond energy production are being recognized as playing major roles in cellular health and dysfunction. This review is aimed at summarizing what is known regarding mitochondrial contributions to pathogenesis of lung diseases. Emphasis is given to understanding the importance of structural and functional aspects of mitochondria in both normal cellular function (based on knowledge from other cell types) and in development and modulation of lung diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Emerging techniques that allow examination of mitochondria, and potential strategies to target mitochondria in the treatment of lung diseases are also discussed.

引用

页码：631 / 646

页数：16

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