Isolated limb perfusion of soft tissue sarcomas: A comprehensive review of literature

被引:15
作者
Seinen, Jojanneke M. [1 ]
Hoekstra, Harald J. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Surg Oncol, NL-9700 AB Groningen, Netherlands
关键词
Isolated limb perfusion; Soft tissue sarcoma; Historical overview; New developments; TUMOR-NECROSIS-FACTOR; ISOLATED REGIONAL PERFUSION; EXTERNAL-BEAM RADIOTHERAPY; HYPERTHERMIC-ANTIBLASTIC PERFUSION; FACTOR-ALPHA; TNF-ALPHA; RADIATION-THERAPY; INTERFERON-GAMMA; SURGICAL RESECTION; MALIGNANT-MELANOMA;
D O I
10.1016/j.ctrv.2012.10.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Patients with primary irresectable, locally advanced soft tissue sarcomas of the limbs form a challenging group for the treating physician. Multimodality treatment is necessary to guarantee optimal limb salvage and survival rates. Since the introduction of isolated limb perfusion in the late fifties, several treatment regimens have been proposed. Isolated perfusion with melphalan and TNF-alpha, as part of a multimodality treatment, is regarded as the current best treatment option today. Ongoing studies are investigating potential benefit of other doses, new chemotherapeutic agents and new techniques in perfusion and radiotherapy. This article provides a historical overview of published literature and insight in upcoming treatment techniques. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:569 / 577
页数:9
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