ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress. ABCB10 is therefore a potential therapeutic target for diseases in which increased mitochondrial reactive oxygen species production and oxidative stress play a major role. The crystal structure of apo-ABCB10 shows a classic exporter fold ABC transporter structure, in an open-inwards conformation, ready to bind the substrate or nucleotide from the inner mitochondrial matrix or membrane. Unexpectedly, however, ABCB10 adopts an open-inwards conformation when complexed with nonhydrolysable ATP analogs, in contrast to other transporter structures which adopt an open-outwards conformation in complex with ATP. The three complexes of ABCB10/ATP analogs reported here showed varying degrees of opening of the transport substrate binding site, indicating that in this conformation there is some flexibility between the two halves of the protein. These structures suggest that the observed plasticity, together with a portal between two helices in the transmembrane region of ABCB10, assist transport substrate entry into the substrate binding cavity. These structures indicate that ABC transporters may exist in an open-inwards conformation when nucleotide is bound. We discuss ways in which this observation can be aligned with the current views on mechanisms of ABC transporters.
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Aller, Stephen G.
;
Yu, Jodie
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h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Yu, Jodie
;
Ward, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Ward, Andrew
;
Weng, Yue
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R ChinaScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Weng, Yue
;
Chittaboina, Srinivas
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Chittaboina, Srinivas
;
Zhuo, Rupeng
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Zhuo, Rupeng
;
Harrell, Patina M.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Harrell, Patina M.
;
Trinh, Yenphuong T.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Trinh, Yenphuong T.
;
Zhang, Qinghai
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Zhang, Qinghai
;
Urbatsch, Ina L.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Urbatsch, Ina L.
;
Chang, Geoffrey
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Ashkenazy, Haim
;
Erez, Elana
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Erez, Elana
;
Martz, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USATel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Martz, Eric
;
Pupko, Tal
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Pupko, Tal
;
Ben-Tal, Nir
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
机构:
Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Childrens Hosp Boston, Dept Med, Div Hematol Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Chen, Wen
;
Dailey, Harry A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
Univ Georgia, Dept Biochem, Athens, GA 30602 USA
Univ Georgia, Dept Mol Biol, Athens, GA 30602 USA
Univ Georgia, Biomed & Hlth Sci Inst, Athens, GA 30602 USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Dailey, Harry A.
;
Paw, Barry H.
论文数: 0引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Childrens Hosp Boston, Dept Med, Div Hematol Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Chen, Wen
;
Paradkar, Prasad N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Paradkar, Prasad N.
;
Li, Liangtao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Li, Liangtao
;
Pierce, Eric L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Pierce, Eric L.
;
Langer, Nathaniel B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Langer, Nathaniel B.
;
Takahashi-Makise, Naoko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Takahashi-Makise, Naoko
;
Hyde, Brigham B.
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Hyde, Brigham B.
;
Shirihai, Orian S.
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Shirihai, Orian S.
;
Ward, Diane M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Ward, Diane M.
;
Kaplan, Jerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Kaplan, Jerry
;
Paw, Barry H.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Aller, Stephen G.
;
Yu, Jodie
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Yu, Jodie
;
Ward, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Ward, Andrew
;
Weng, Yue
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R ChinaScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Weng, Yue
;
Chittaboina, Srinivas
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Chittaboina, Srinivas
;
Zhuo, Rupeng
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Zhuo, Rupeng
;
Harrell, Patina M.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Harrell, Patina M.
;
Trinh, Yenphuong T.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Trinh, Yenphuong T.
;
Zhang, Qinghai
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Zhang, Qinghai
;
Urbatsch, Ina L.
论文数: 0引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
Urbatsch, Ina L.
;
Chang, Geoffrey
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Ashkenazy, Haim
;
Erez, Elana
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Erez, Elana
;
Martz, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USATel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Martz, Eric
;
Pupko, Tal
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
Pupko, Tal
;
Ben-Tal, Nir
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
机构:
Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Childrens Hosp Boston, Dept Med, Div Hematol Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Chen, Wen
;
Dailey, Harry A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
Univ Georgia, Dept Biochem, Athens, GA 30602 USA
Univ Georgia, Dept Mol Biol, Athens, GA 30602 USA
Univ Georgia, Biomed & Hlth Sci Inst, Athens, GA 30602 USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Dailey, Harry A.
;
Paw, Barry H.
论文数: 0引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Childrens Hosp Boston, Dept Med, Div Hematol Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Chen, Wen
;
Paradkar, Prasad N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Paradkar, Prasad N.
;
Li, Liangtao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Li, Liangtao
;
Pierce, Eric L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Pierce, Eric L.
;
Langer, Nathaniel B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Langer, Nathaniel B.
;
Takahashi-Makise, Naoko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Takahashi-Makise, Naoko
;
Hyde, Brigham B.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Hyde, Brigham B.
;
Shirihai, Orian S.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Shirihai, Orian S.
;
Ward, Diane M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Ward, Diane M.
;
Kaplan, Jerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Kaplan, Jerry
;
Paw, Barry H.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA
Harvard Univ, Div Hematol Oncol, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA