MET Receptor Juxtamembrane Exon 14 Alternative Spliced Variant: Novel Cancer Genomic Predictive Biomarker

被引：33

作者：

Ma, Patrick C. ^{[1
,2
]}

机构：

[1] W Virginia Univ, Mary Babb Randolph Canc Ctr, Robert C Byrd Hlth Sci Ctr, Morgantown, WV 26506 USA

[2] West Virginia Clin & Translat Sci Inst, Morgantown, WV USA

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 08期

关键词：

CELL LUNG-CANCER; C-MET; MUTATIONS; INHIBITION;

D O I：

10.1158/2159-8290.CD-15-0769

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical studies on MET-targeting cancer therapeutics have yielded mixed results in recent years, and MET-relevant predictive biomarkers remain elusive. New studies now reveal METex14 alternative splicing aberrations to represent potential predictive cancer genomic biomarker, hence renewing optimism and directions in the quest for optimized MET-targeting personalized cancer therapy. (C) 2015 AACR.

引用

页码：802 / 805

页数：4

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