Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic

被引：116

作者：

Biswas, R. ^{[1
]}

Ghosh, P. ^{[1
]}

Banerjee, N. ^{[1
]}

Das, J. K. ^{[2
]}

Sau, T. ^{[3
]}

Banerjee, A. ^{[1
,4
]}

Roy, S.

Ganguly, S. ^{[5
]}

Chatterjee, M. ^{[5
]}

Mukherjee, A. ^{[6
]}

Giri, A. K. ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Mol & Human Genet Div, Kolkata 700032, India

[2] W Bank Hosp, Dept Dermatol, Howrah 711109, India

[3] Calcutta Natl Med Coll, Dept Med, Kolkata 700014, India

[4] Indian Inst Chem Biol, Div Infect Dis & Immunol, Kolkata 700032, India

[5] Postgrad Inst Med Educ & Res, Dept Pharmacol, Kolkata 700020, India

[6] Univ Calcutta, Dept Bot, Ctr Adv Study, Kolkata 700019, India

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2008年 / 27卷 / 05期

关键词：

concanavalin A; cytometric bead array; lymphocytes;

D O I：

10.1177/0960327108094607

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Over six million people in nine districts of West Bengal, India are exposed to very high levels of arsenic primarily through their drinking water. More than 300,000 people showed arsenic-induced skin lesions in these districts. This is regarded as the greatest arsenic calamity in the world. Chronic arsenicosis causes varied dermatological signs ranging from pigmentation changes, hyperkeratosis to non-melanocytic cancer of skin, and also malignancies in different internal organs. Higher incidences of opportunistic infections are found in the arsenic-exposed individuals, indicating that their immune systems may be impaired somehow. We have thus investigated the effect of arsenic on T-cell proliferation and cytokine secretion in 20 individuals with arsenic-induced skin lesions and compared the results with 18 arsenic-unexposed individuals. A marked dose-dependent suppression of Concanavalin A (Con A) induced T-cell proliferation was observed in the arsenic-exposed individuals compared with the unexposed (P < 0.001) individuals. This correlated with a significant decrease in the levels of secreted cytokines by the T cells (TNF-alpha, IFN-gamma, IL2, IL10, IL5, and IL4) in the exposed individuals (P < 0.001). Thus it can be inferred that arsenic exposure can cause immunosuppression in humans.

引用

页码：381 / 386

页数：6

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