High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study

被引：52

作者：

Osunkwo, Ifeyinwa ^{[1
,2
]}

Ziegler, Thomas R. ^{[3
]}

Alvarez, Jessica ^{[3
]}

McCracken, Courtney ^{[2
]}

Cherry, Korin ^{[1
]}

Osunkwo, Chinyere E. ^{[1
]}

Ofori-Acquah, Solomon F. ^{[1
,2
]}

Ghosh, Samit ^{[2
]}

Ogunbobode, Adeolu ^{[2
]}

Rhodes, Jim ^{[1
]}

Eckman, James R. ^{[4
,5
]}

Dampier, Carlton ^{[1
,2
]}

Tangpricha, Vin ^{[3
]}

机构：

[1] Ctr Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders, Atlanta, GA USA

[2] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[3] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA

[4] Emory Univ, Sch Med, Dept Hematol Oncol, Winship Canc Inst, Atlanta, GA USA

[5] Georgia Comprehens Sickle Cell Ctr Grady Mem Hosp, Atlanta, GA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 159卷 / 02期

关键词：

vitamin D; chronic pain; sickle cell; paediatrics; quality of life; QUALITY-OF-LIFE; D DEFICIENCY; PREVALENCE; ADULTS;

D O I：

10.1111/bjh.12019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (40 000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82.5% and 52.5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.

引用

页码：211 / 215

页数：5

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