High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study

被引:52
作者
Osunkwo, Ifeyinwa [1 ,2 ]
Ziegler, Thomas R. [3 ]
Alvarez, Jessica [3 ]
McCracken, Courtney [2 ]
Cherry, Korin [1 ]
Osunkwo, Chinyere E. [1 ]
Ofori-Acquah, Solomon F. [1 ,2 ]
Ghosh, Samit [2 ]
Ogunbobode, Adeolu [2 ]
Rhodes, Jim [1 ]
Eckman, James R. [4 ,5 ]
Dampier, Carlton [1 ,2 ]
Tangpricha, Vin [3 ]
机构
[1] Ctr Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders, Atlanta, GA USA
[2] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA
[3] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA
[4] Emory Univ, Sch Med, Dept Hematol Oncol, Winship Canc Inst, Atlanta, GA USA
[5] Georgia Comprehens Sickle Cell Ctr Grady Mem Hosp, Atlanta, GA USA
关键词
vitamin D; chronic pain; sickle cell; paediatrics; quality of life; QUALITY-OF-LIFE; D DEFICIENCY; PREVALENCE; ADULTS;
D O I
10.1111/bjh.12019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (40 000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82.5% and 52.5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.
引用
收藏
页码:211 / 215
页数:5
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