A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H2S production

被引：47
作者：
Zhang, Li-Li [1 ,2 ]
Zhu, Hui-Kun [3 ]
Zhao, Chun-Chang [1 ,2 ]
Gu, Xian-Feng [3 ]
机构：
[1] East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China
[3] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Near-infrared fluorescence emission; Endogenous H2S detection; Fluvastatin; CYSTATHIONINE GAMMA-LYASE; HYDROGEN-SULFIDE; LIVING CELLS; RAPID DETECTION; SELECTIVE DETECTION; IN-VIVO; REDUCTION; VISUALIZATION; GENERATION; EMISSION;
D O I：
10.1016/j.cclet.2016.07.008
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Most reported fluorescent probes have limitations in practical applications in living systems due to the strong autofluorescence background, construction of probes with near-infrared (NIR) fluorescence emission is an accessible approach for addressing this challenge. We here designed a NIR fluorescent probe for monitoring the endogenous production of H2S in living cells. The designed probe showed significant NIR fluorescence turn-on response to H2S with high selectivity, enabling the sensitive detection H2S. Importantly, the probe could be applied in monitoring the endogenous production of H2S in raw264.7 macrophages. This study showed that fluvastatin can promote the activity of cystathionine gamma-lyase (CSE) for generation H2S. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：218 / 221
页数：4
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