Effects of complete water fasting and regeneration diet on kidney function, oxidative stress and antioxidants

被引：5

作者：

Mojto, V ^{[1
,2
]}

Gvozdjakova, A. ^{[1
,2
]}

Kucharska, J. ^{[1
,2
]}

Rausova, Z. ^{[1
,2
]}

Vancova, O. ^{[1
,2
]}

Valuch, J. ^{[1
,2
]}

机构：

[1] Comenius Univ, Fac Med, Dept Internal Med 3, Limbova 5, SK-83305 Bratislava, Slovakia

[2] Univ Hosp Bratislava, Limbova 5, SK-83305 Bratislava, Slovakia

来源：

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2018年 / 119卷 / 02期

关键词：

antioxidants; body weight; complete water fasting; kidney function; oxidative stress; regeneration diet; CALORIC RESTRICTION; COENZYME Q(10); STARVATION; PLASMA; HEALTH;

D O I：

10.4149/BLL_2018_020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress. BACKGROUND: Therapeutic WF is considered a healing method. METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained. RESULTS: WF increased uric acid and creatinine and decreased glomerular filtration rate. After RD, the parameters were comparable to baseline values. Urea was not affected. Lipid peroxidation (TBARS) decreased and maintained stable after RD. Fasting decreased alpha-tocopherol and increased gamma-tocopherol, no significant changes were found after RD. Coenzyme Q(10) decreased after RD. HDL-cholesterol decreased in WF. Total- and LDL-cholesterol decreased after RD. Other biochemical parameters were within the range of reference values. CONCLUSIONS: The effect of the complete fasting on kidney function was manifested by hyperuricemia. Renal function was slightly decreased, however maintained within the reference values. After RD, it returned to baseline values. The positive effect of the complete water fasting was in the reduction of oxidative stress, body weight and blood pressure.

引用

页码：107 / 111

页数：5

共 25 条

[21] Starvation in humans: Evolutionary background and contemporary implications [J].