Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

被引：22

作者：

Bruce-Vanderpuije, Pennante ^{[1
,2
]}

Megson, David ^{[3
,4
]}

Jobst, Karl ^{[5
]}

Jones, Gareth Rhys ^{[6
]}

Reiner, Eric ^{[5
]}

Sandau, Court D. ^{[4
,7
]}

Clarke, Edith ^{[8
]}

Adu-Kumi, Sam ^{[9
]}

Gardella, Joseph A., Jr. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

[2] CSIR Water Res Inst, POB AH 38, Achimota, Accra, Ghana

[3] Manchester Metropolitan Univ, Sch Sci & Environm, Manchester, Lancs, England

[4] Chem Matters Inc, Suite 405,104-1240 Kensington Rd NW, Calgary, AB T2N 3P7, Canada

[5] Ontario Minist Environm Conservat & Pk, Lab Serv Branch, Toronto, ON M9P 3V6, Canada

[6] Waters Corp, Manchester, Lancs, England

[7] Mt Royal Univ, Dept Earth & Environm Sci, Fac Sci & Technol, 4825 Mt Royal Gate SW, Calgary, AB T3E 6K6, Canada

[8] Minist Hlth, Ghana Hlth Serv, Occupat & Environm Hlth Unit, Accra, Ghana

[9] Environm Protect Agcy, POB MB 326,Minist PO, Accra, Ghana

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2019年 / 673卷

关键词：

Ghana; Background concentrations; Dioxins; Dioxin-like compounds; Serum; Pregnant women; PERSISTENT ORGANIC POLLUTANTS; TANDEM MASS-SPECTROMETRY; TOXIC EQUIVALENCY FACTORS; ORGANOCHLORINE PESTICIDES; GAS-CHROMATOGRAPHY; PRENATAL EXPOSURE; FLAME RETARDANTS; DELIVERING WOMEN; DIETARY EXPOSURE; US POPULATION;

D O I：

10.1016/j.scitotenv.2019.04.060

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dIPCBs) in sera of primiparous Ghanaians. Our sample selection includes 34 participants from two municipalities (Accra and Tema), and explores contributions from environmental and dietary exposures using questionnaire data. Sample preparation involved C-18 solid phase extraction, purification with acidified silica and lipid removal cartridges, and detection with gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. The calculated average toxic equivalent concentration was 5.3 pg TEQg 1w, with contributions from dIPCBs (125 pg TEQ/g lw), PCDD,Ts (3.10 pg TEQ/g lw), PBDID/Fs (0.49 pg TEQ/g lw) and PXDD/Fs (0.50 pg TEQ/g lw). The calculated total TEQ concentration was lower than background TEQ concentrations repotted in sera of pregnant women globally. Positive correlations were obtained for total dioxins and DLC concentrations with age and Body Mass Index (BMI). Dietary intake of seafood and dairy products had a strong influence on PCDD/l and d1PCB concentrations. Statistically significant differences were observed for dioxins and DLCs in participants from Accra (in close proximity to Agbogbloshie e-waste site) and Tema. Given the significant TEQ contribution of PBDID/Es and PXDD/Es (similar to 20%), it is essential to explore these classes of dioxins and DLCs in future biomonitoring studies as they may pose health risks, and add extra diagnostic information in source exposure investigations. (C) 2019 Published by Elsevier B.V.

引用

页码：631 / 642

页数：12

共 71 条

[31] Determination of Halogenated Flame Retardants Using Gas Chromatography with Atmospheric Pressure Chemical Ionization (APCI) and a High-Resolution Quadrupole Time-of-Flight Mass Spectrometer (HRqTOFMS) [J].

Megson, David ;

Robson, Matthew ;

Jobst, Karl J. ;

Helm, Paul A. ;

Reiner, Eric J. .

ANALYTICAL CHEMISTRY, 2016, 88 (23) :11406-11411

[32]

Minitab, 2010, STAT SOFTW COMP SOFT

[33] Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study [J].

Miyashita, Chihiro ;

Araki, Atsuko ;

Mitsui, Takahiko ;

Itoh, Sachiko ;

Goudarzi, Houman ;

Sasaki, Seiko ;

Kajiwara, Jumboku ;

Hori, Tsuguhide ;

Cho, Kazutoshi ;

Moriya, Kimihiko ;

Shinohara, Nobuo ;

Nonomura, Katsuya ;

Kishi, Reiko .

ENVIRONMENT INTERNATIONAL, 2018, 117 :175-185

[34] Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human breast milk and associated health risks to nursing infants in Northern Tanzania [J].

Muller, M. H. B. ;

Polder, A. ;

Brynildsrud, O. B. ;

Karimi, M. ;

Lie, E. ;

Manyilizu, W. B. ;

Mdegela, R. H. ;

Mokiti, F. ;

Murtadha, M. ;

Nonga, H. E. ;

Skaare, J. U. ;

Lyche, J. L. .

ENVIRONMENTAL RESEARCH, 2017, 154 :425-434

[35] Analysis of mixed halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/PXDFs) in soil by gas chromatography tandem mass spectrometry (GC-MS/MS) [J].

Myers, Anne L. ;

Mabury, Scott A. ;

Reiner, Eric J. .

CHEMOSPHERE, 2012, 87 (09) :1063-1069

[36]

Nakajima S, 2005, ENV HLTH PERSPECT, V114, P773

[37] Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children: Sapporo cohort study [J].

Nakajima, Sonomi ;

Saijo, Yasuaki ;

Miyashita, Chihiro ;

Ikeno, Tamiko ;

Sasaki, Seiko ;

Kajiwara, Junboku ;

Kishi, Reiko .

ENVIRONMENTAL RESEARCH, 2017, 159 :222-231

[38] Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues [J].

Needham, Larry L. ;

Grandjean, Philippe ;

Heinzow, Birger ;

Jorgensen, Poul J. ;

Nielsen, Flemming ;

Patterson, Donald G., Jr. ;

Sjoedin, Andreas ;

Turner, Wayman E. ;

Weihe, Pal .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2011, 45 (03) :1121-1126

[39] Accumulation of persistent organochlorine contaminants in milk and serum of farmers from Ghana [J].

Ntow, William J. ;

Tagoe, Laud Mike ;

Drechsel, Pay ;

Kelderman, Peter ;

Gijzen, Fluub J. ;

Nyarko, Elvis .

ENVIRONMENTAL RESEARCH, 2008, 106 (01) :17-26

[40] Organochlorine pesticides in water, sediment, crops, and human fluids in a farming community in Ghana [J].

Ntow, WJ .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2001, 40 (04) :557-563

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