2′,3′-dideoxy-2′,3′-didehydro-β-L-5-fluorocytidine (β-L-FD4C) exhibits a more potent antiviral effect than lamivudine in chronically WHV infected woodchucks

被引:0
|
作者
Le Guerhier, F
Pichoud, C
Guerret, S
Peyrol, S
Chevallier, M
King, I
Cheng, YC
Trzpo, C
Zoulim, F
机构
[1] INSERM, U271, F-69008 Lyon, France
[2] Merieux Lab, Lyon, France
[3] VION Pharmaceut, New Haven, CT USA
[4] Yale Univ, New Haven, CT USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
733
引用
收藏
页码:344A / 344A
页数:1
相关论文
共 10 条
  • [1] Characterization of the antiviral effect of 2′,3′-dideoxy-2′, 3′-didehydro-β-L-5-fluorocytidine in the duck hepatitis B virus infection model
    Le Guerhier, F
    Pichoud, C
    Guerret, S
    Chevallier, M
    Jamard, C
    Hantz, O
    Li, XY
    Chen, SH
    King, I
    Trépo, C
    Cheng, YC
    Zoulim, F
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (01) : 111 - 122
  • [2] Antiviral activity of β-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus
    Le Guerhier, F
    Pichoud, C
    Jamard, C
    Guerret, S
    Chevallier, M
    Peyrol, S
    Hantz, O
    King, I
    Trépo, C
    Cheng, YC
    Zoulim, F
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (04) : 1065 - 1077
  • [3] Anti-hepatitis B virus activity and metabolism of 2′,3′-dideoxy-2′,3′-didehydro-β-L(-)-5-fluorocytidine
    Zhu, YL
    Dutschman, GE
    Liu, SH
    Bridges, EG
    Cheng, YC
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) : 1805 - 1810
  • [4] Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy-2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro
    Lin, TS
    Luo, MZ
    Liu, MC
    Zhu, YL
    Gullen, E
    Dutschman, GE
    Cheng, YC
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (09) : 1757 - 1759
  • [5] Synthesis and potent anti-HIV activity of L-2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro-4′-thiocytidine
    Choi, Y
    Choo, H
    Chong, Y
    Lee, S
    Olgen, S
    Schinazi, RF
    Chu, CK
    ORGANIC LETTERS, 2002, 4 (02) : 305 - 307
  • [6] Metabolism of 2′,3′-dideoxy-2′,3′-didehydro-β-L(-)-5-flurocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus β-D(+) nucleoside analogs in vitro
    Dutschman, GE
    Bridges, EG
    Liu, SH
    Gullen, E
    Guo, X
    Kukhanova, M
    Cheng, YC
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) : 1799 - 1804
  • [7] Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-alpha-L-threofuranosyl] adenine and its 4'-thio analog as potential antiviral agents
    Kikuchi, Y
    Kurata, H
    Nishiyama, S
    Yamamura, S
    Kato, K
    TETRAHEDRON LETTERS, 1997, 38 (27) : 4795 - 4798
  • [8] Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (Troxacitabine and β-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (Gemcitabine and β-D-arabinofuranosylcytosine)
    Lam, W
    Park, SY
    Leung, CH
    Cheng, YC
    MOLECULAR PHARMACOLOGY, 2006, 69 (05) : 1607 - 1614
  • [9] Synthesis and antiviral activity of aryl phosphoramidate derivatives of β-D- and β-L-C-5-Substituted 2′,3′-didehydro-2′,3′-dideoxy-uridine bearing linker arms
    Ladurée, D
    Fossey, C
    Delbederi, Z
    Sugeac, E
    Schmidt, S
    Laumond, G
    Aubertin, AM
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2005, 20 (06) : 533 - 549