Characterization of the species-specific acid-base equilibria of adrenaline and noradrenaline

被引：4

作者：

Mirzahosseini, Arash ^{[1
,2
]}

Palla, Tamas ^{[1
,2
]}

Orgovan, Gabor ^{[1
,2
]}

Toth, Gergo ^{[1
,2
]}

Noszal, Bela ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Dept Pharmaceut Chem, Hogyes E U 9, H-1092 Budapest, Hungary

[2] Hungarian Acad Sci, Res Grp Drugs Abuse & Doping Agents, Budapest, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2019年 / 170卷

关键词：

Catecholamine; Epinephrine; pK(a); Microspeciation; NMR-pH titration; DISSOCIATION-CONSTANTS; METAL-IONS; COMPLEXES; DOPAMINE; IONIZATION; STABILITY; AMINES; PH;

D O I：

10.1016/j.jpba.2019.02.035

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Adrenaline, noradrenaline, the biogenic catecholamines of vital importance, and four closely related compounds were studied by H-1 NMR-pH titrations, and the resulting acid-base properties are quantified in terms of three macroscopic and twelve microscopic protonation constants for both molecules. The species-specific basicities are interpreted by means of inductive and shielding effects by comparing the protonation constants of the catecholamines, including dopamine. The site-specific basicities determined this way could be key parameters for the interpretation of biochemical behavior. (C) 2019 Published by Elsevier B.V.

引用

页码：215 / 219

页数：5

共 25 条

[1] COPPER(II), COBALT(II), AND NICKEL(II) COMPLEXES OF VARIOUS ANTIHISTAMINIC COMPOUNDS - THEIR STABILITY AND THERMODYNAMIC VALUES [J].