Remote Ischemic Preconditioning for Coronary Artery Bypass Graft Operations

被引：20
|
作者：
Sabbagh, Salah
Salzman, Michele M. Henry
Kloner, Robert A.
Simkhovich, Boris Z.
Rezkalla, Shereif H.
机构：
[1] Marshfield Clin Fdn Med Res & Educ, Dept Internal Med, Marshfield, WI 54449 USA
[2] Marshfield Clin Fdn Med Res & Educ, Marshfield Clin Res Fdn, Marshfield, WI 54449 USA
[3] Univ So Calif, Keck Sch Med, Good Samaritan Hosp, Inst Heart, Los Angeles, CA 90033 USA
[4] Marshfield Clin Fdn Med Res & Educ, Dept Cardiol, Marshfield, WI 54449 USA
来源：
ANNALS OF THORACIC SURGERY | 2013年 / 96卷 / 02期
关键词：
RANDOMIZED-CONTROLLED-TRIAL; CYTOCHROME-P450 EPOXYGENASE PATHWAY; CHANNEL-DEPENDENT MECHANISM; MYOCARDIAL PROTECTION; REPERFUSION INJURY; ISCHEMIA/REPERFUSION INJURY; INTERMITTENT ISCHEMIA; VOLATILE ANESTHETICS; CLINICAL-APPLICATION; INDUCED NEPHROPATHY;
D O I：
10.1016/j.athoracsur.2013.02.049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ischemia-reperfusion injury occurs during coronary artery bypass graft operations. Strategies are needed to lower the extent of damage. Attempts to find these strategies have been occurring for more than 40 years, with remote ischemic preconditioning being one method. This review provides a look at potential mechanisms involved in remote ischemic preconditioning, experimental evidence supporting it, clinical studies that support and negate it, and potential reasons for differences between clinical studies. With remote ischemic preconditioning having the potential to better clinical outcomes in patients undergoing coronary artery bypass graft operations, a large clinical trial needs to be undertaken to better assess its practical clinical application. (C) 2013 by The Society of Thoracic Surgeons
引用
收藏
页码：727 / 736
页数：10
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