Cytomegalovirus: A probable cause of steroid-refractory ulcerative colitis

被引：8

作者：

Xue, Meng ^{[1
]}

Chen, Shu Jie ^{[1
]}

Wang, Liang Jing ^{[2
]}

Du, Ying ^{[1
]}

Si, Jian Min ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Gastroenterol, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Gastroenterol, Affiliated Hosp 2, Hangzhou 310016, Zhejiang, Peoples R China

来源：

JOURNAL OF DIGESTIVE DISEASES | 2013年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

cytomegalovirus; ganciclovir; immune dysregulation; steroid-refractory; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; IMMUNE-RESPONSE; INFECTION; PREVALENCE; RESISTANCE; CELLS; CYCLOSPORINE; EXPRESSION; THERAPIES; VIRUS;

D O I：

10.1111/1751-2980.12037

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with cytomegalovirus are usually non-responders to steroid, while antiviral drugs could induce remission. Cytomegalovirus should be suggested as a probable cause of steroid-refractory UC based on the clinical data in the literatures.

引用

页码：160 / 165

页数：6

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