Synthesis of Marine Natural Products with Antimalarial Activity

被引：18
作者：
Mancini, Ines [1 ]
Guella, Graziano [1 ]
Defant, Andrea [1 ]
机构：
[1] Univ Trent, Ctr Integrat Biol, Bioorgan Chem Lab, Dept Phys, I-38050 Trento, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 12期
关键词：
Natural products; marine metabolites; drug discovery; synthesis; retrosynthetic analysis; antiprotozoal; antimalarial; antiplasmodial;
D O I：
10.2174/138955708786141007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structure-activity relationship (SAR) studies and their mechanism of action.
引用
收藏
页码：1265 / 1284
页数：20
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