Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice

被引：5

作者：

Iwata, Hiroki ^{[1
,2
]}

Tsuchiya, Shizuko ^{[1
]}

Ueno, Koichi ^{[2
]}

Nakamura, Tomonori ^{[1
,2
]}

Yano, Shingo ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Mol Pharmacol & Pharmacotherapy, Chuo Ku, Chiba 2608675, Japan

[2] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Geriatr Pharmacol & Therapeut, Chuo Ku, Chiba 2608675, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 600卷 / 1-3期

关键词：

Morphine; Morphine-6-glucuronide; Morphine-3-glucuronide; Circular muscle contraction; Mouse ileum;

D O I：

10.1016/j.ejphar.2008.10.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：130 / 132

页数：3

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