GET-SERF, a new gradient encoded SERF experiment for the trivial edition of 1H-19F couplings

被引：23

作者：

Di Pietro, Maria Enrica ^{[1
,2
]}

Aroulanda, Christie ^{[1
]}

Merlet, Denis ^{[1
]}

机构：

[1] Univ Paris 11, UMR 8182, ICMMO, Equipe RMN Milieu Oriente, Orsay, France

[2] Univ Calabria, Dipartimento Chim, LXNMRSCAn, Arcavacata Di Rende, CS, Italy

来源：

JOURNAL OF MAGNETIC RESONANCE | 2013年 / 234卷

关键词：

NMR spectroscopy; Fluorinated compounds; Couplings extraction; Spatial encoding; SERF experiment; MEDICINAL CHEMISTRY; DIPOLAR COUPLINGS; NMR-SPECTROSCOPY; H-1-NMR SPECTRA; FLUORINE; CONSTANTS; ENANTIOMERS; DEPENDENCE; PHARMACEUTICALS; HETERONUCLEAR;

D O I：

10.1016/j.jmr.2013.06.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new spatially encoded heteronuclear H-1-F-19 selective refocusing NMR experiment (GET-SERF) is proposed. This sequence allows editing in one single 2D experiment all couplings between a selected fluorine site and all the proton nuclei of the molecule. Its efficiency is illustrated in the case of diflunisal, a difluorinated anti-inflammatory drug, in isotropic and anisotropic media. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：101 / 105

页数：5

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