miRNA-101: A potential target for tumor therapy

被引：40
作者：
Gui, Ting [1 ]
Shen, Keng [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100005, Peoples R China
来源：
CANCER EPIDEMIOLOGY | 2012年 / 36卷 / 06期
关键词：
miRNA-101; Biogenesis; Target; Epigenetic regulation; Tumorigenesis; Gene therapy; MESSENGER-RNAS; MICRORNA; EXPRESSION; CANCER; EZH2; TRANSCRIPTION; TRANSLATION; CLEAVAGE;
D O I：
10.1016/j.canep.2012.05.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
microRNAs are genomically encoded small non-coding RNAs that regulate genetic information by controlling stability or translation of mRNAs. Down-regulated expression of microRNA-101 (miRNA-101) has been found in a variety of cancers, and associated with the invasion and progression of malignancies. Recent advances in the understanding of miRNA-101 biogenesis, target recognition and participation in regulatory pathways demonstrate a role for miRNA-101 in tumorigenesis. miRNA-101 gene therapy is of great potentiality to be a new modality for treatment of cancers. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：537 / 540
页数：4
相关论文
共 39 条
[11]   The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2 [J].
Friedman, Jeffrey M. ;
Liang, Gangning ;
Liu, Chun-Chi ;
Wolff, Erika M. ;
Tsai, Yvonne C. ;
Ye, Wei ;
Zhou, Xianghong ;
Jones, Peter A. .
CANCER RESEARCH, 2009, 69 (06) :2623-2629
[12]   Most mammalian mRNAs are conserved targets of microRNAs [J].
Friedman, Robin C. ;
Farh, Kyle Kai-How ;
Burge, Christopher B. ;
Bartel, David P. .
GENOME RESEARCH, 2009, 19 (01) :92-105
[13]   miRBase: microRNA sequences, targets and gene nomenclature [J].
Griffiths-Jones, Sam ;
Grocock, Russell J. ;
van Dongen, Stijn ;
Bateman, Alex ;
Enright, Anton J. .
NUCLEIC ACIDS RESEARCH, 2006, 34 :D140-D144
[14]   MicroRNA-196a & microRNA-101 expression in Barrett's oesophagus in patients with medically and surgically treated gastro-oesophageal reflux [J].
Haiart S. ;
Watson D.I. ;
Leong M.P. ;
Astill D. ;
Bright T. ;
Hussey D.J. .
BMC Research Notes, 4 (1)
[15]   Micrornas: Small RNAs with a big role in gene regulation [J].
He, L ;
Hannon, GJ .
NATURE REVIEWS GENETICS, 2004, 5 (07) :522-531
[16]   p53 enters the MicroRNA world [J].
Hermeking, Heiko .
CANCER CELL, 2007, 12 (05) :414-418
[17]   MicroRNA signatures in human ovarian cancer [J].
Iorio, Marilena V. ;
Visone, Rosa ;
Di Leva, Gianpiero ;
Donati, Valentina ;
Petrocca, Fabio ;
Casalini, Patrizia ;
Taccioli, Cristian ;
Volinia, Stefano ;
Liu, Chang-Gong ;
Alder, Hansjuerg ;
Calin, George A. ;
Menard, Sylvie ;
Croce, Carlo M. .
CANCER RESEARCH, 2007, 67 (18) :8699-8707
[18]   The developmental role of microRNA in plants [J].
Kidner, CA ;
Martienssen, RA .
CURRENT OPINION IN PLANT BIOLOGY, 2005, 8 (01) :38-44
[19]   MicroRNA-101 Regulates Expression of the v-fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Oncogene in Human Hepatocellular Carcinoma [J].
Li, Shuai ;
Fu, Hanjiang ;
Wang, Yulan ;
Tie, Yi ;
Ying, Ruiyun ;
Zhu, Jie ;
Sun, Zhixian ;
Wei, Lixin ;
Zheng, Xiaofei .
HEPATOLOGY, 2009, 49 (04) :1194-1202
[20]   Novel modes of protein-RNA recognition in the RNAi pathway [J].
Lingel, A ;
Sattler, M .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (01) :107-115
1234