miRNA-101: A potential target for tumor therapy

被引：40

作者：

Gui, Ting ^{[1
]}

Shen, Keng ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100005, Peoples R China

来源：

CANCER EPIDEMIOLOGY | 2012年 / 36卷 / 06期

关键词：

miRNA-101; Biogenesis; Target; Epigenetic regulation; Tumorigenesis; Gene therapy; MESSENGER-RNAS; MICRORNA; EXPRESSION; CANCER; EZH2; TRANSCRIPTION; TRANSLATION; CLEAVAGE;

D O I：

10.1016/j.canep.2012.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

microRNAs are genomically encoded small non-coding RNAs that regulate genetic information by controlling stability or translation of mRNAs. Down-regulated expression of microRNA-101 (miRNA-101) has been found in a variety of cancers, and associated with the invasion and progression of malignancies. Recent advances in the understanding of miRNA-101 biogenesis, target recognition and participation in regulatory pathways demonstrate a role for miRNA-101 in tumorigenesis. miRNA-101 gene therapy is of great potentiality to be a new modality for treatment of cancers. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：537 / 540

页数：4

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