Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury

被引：19

作者：

Zhang, Li ^{[1
]}

Gan, Weidong ^{[1
]}

An, Guoyao ^{[1
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Sch Traumatol & Orthoped, Fuzhou 350108, Fujian Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 36期

基金：

中国国家自然科学基金;

关键词：

Tanshinone IIa; Danshen; spinal ischemia/reperfusion injury; heat shock protein 70; Bcl-2; Bax; cell apoptosis; Chinese medicine; neural regeneration; TISSUE DISTRIBUTION; REPERFUSION INJURY; APOPTOSIS; HSP70; MODEL;

D O I：

10.3969/j.issn.1673-5374.2012.36.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.

引用

页码：2882 / 2888

页数：7

共 28 条

[1]

[Anonymous], CHIN PHARM 1

[2] A Mouse Model of Ischemic Spinal Cord Injury with Delayed Paralysis Caused by Aortic Cross-clamping [J].

Awad, Hamdy ;

Ankeny, Daniel P. ;

Guan, Zhen ;

Wei, Ping ;

McTigue, Dana M. ;

Popovich, Phillip G. .

ANESTHESIOLOGY, 2010, 113 (04) :880-891

[3] Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method [J].

Bi, Hui-chang ;

Law, Francis C. P. ;

Zhong, Guo-ping ;

Xu, Chen-shu ;

Pan, Ying ;

Ding, Liang ;

Chen, Xiao ;

Zhao, Li-zi ;

Xu, Qiong ;

Huang, Min .

BIOMEDICAL CHROMATOGRAPHY, 2007, 21 (05) :473-479

[4]

DU SC, 2012, CELL MOL BIOL NOIS S, V58

[5] The Chinese interbank repo market: An analysis of term premiums [J].

Fan, LZ ;

Zhang, C .

JOURNAL OF FUTURES MARKETS, 2006, 26 (02) :153-167

[6] Effects of adrenergic agents on stress-induced brain microstructural and immunochemical changes in adult male Wistar rats [J].

Fan, Shu Juan ;

Jiang, Hong ;

Yang, Le-Jin ;

Liu, Xin ;

Song, Jing ;

Pan, Fang .

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 2011, 193 (05) :418-424

[7] The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system [J].

Franklin, TB ;

Krueger-Naug, AM ;

Clarke, DB ;

Arrigo, AP ;

Currie, RW .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2005, 21 (05) :379-392

[8] Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion [J].

Hao, Haiping ;

Wang, Guangji ;

Cui, Nan ;

Li, Jing ;

Xie, Lin ;

Ding, Zuoqi .

PLANTA MEDICA, 2006, 72 (14) :1311-1317

[9]

Jin XL, 2011, ZHONGGUO SHIYONG SHE, P28

[10]

Li H, 2009, SHIZHEN GUOYI GUOYAO, V20, P82

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