Application of a nanostructured sensor based on graphene- and ethyl 2-(4-ferrocenyl[1,2,3]triazol-1-yl)acetate-modified carbon paste electrode for determination of methyldopa in the presence of phenylephrine and guaifenesin

被引：17
作者：
Beitollahi, Hadi [1 ]
Movlaee, Kaveh [2 ]
Ganjali, Mohammad Reza [2 ,3 ]
Norouzi, Parviz [2 ,3 ]
Hosseinzadeh, Rahman [4 ]
机构：
[1] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Dept Environm, Kerman, Iran
[2] Univ Tehran, Ctr Excellence Electrochem, Fac Chem, Tehran, Iran
[3] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Biosensor Res Ctr, Tehran, Iran
[4] Univ Mazandaran, Dept Organ Chem, Fac Chem, Babol Sar, Iran
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 04期
关键词：
carbon paste electrode; graphene; guaifenesin; methyldopa; phenylephrine; VOLTAMMETRIC DETERMINATION; HUMAN PLASMA; 1ST REPORT; ELECTROCHEMICAL DETERMINATION; KETOROLAC TROMETHAMINE; IONIC LIQUIDS; URIC-ACID; VALIDATION; 3-O-METHYLDOPA; HYDROCHLORIDE;
D O I：
10.1002/aoc.4243
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We introduce a new method to determine methyldopa without the interference of phenylephrine and guaifenesin. For this purpose, a carbon paste electrode was modified with graphene and ethyl 2-(4-ferrocenyl[1,2,3]triazol-1-yl)acetate. According to electrochemical studies, oxidation current of methyldopa on the surface of the modified electrode increased and shifted towards negative potentials. This modified electrode demonstrated two linear ranges of 0.4-30.0 M and 30.0-500.0 M with a detection limit of 0.08 M. No change was observed in the sensitivity of the modified electrode towards methyldopa in the presence of phenylephrine and guaifenesin, which enables the simultaneous or independent measurement of the three moieties. The efficiency of the proposed modified electrode was evaluated through the determination of these substances in real samples.
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页数：10
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