Sensitive Determination of Anticancer Drug Methotrexate Using Graphite Oxide-Nafion Modified Glassy Carbon Electrode

被引：18

作者：

Huang, Deqian ^{[1
,2
]}

Wu, Hai ^{[1
,2
]}

Zhu, Yuyang ^{[1
,2
]}

Su, Huijuan ^{[1
,2
]}

Zhang, Hong ^{[1
,2
]}

Sheng, Liangquan ^{[1
,2
]}

Liu, Zhaodi ^{[1
,2
]}

Xu, Huajie ^{[1
,2
]}

Song, Chongfu ^{[1
,2
]}

机构：

[1] Fuyang Normal Univ, Sch Chem & Mat Engn, Fuyang 236037, Anhui, Peoples R China

[2] Anhui Prov Key Lab Degradat & Monitoring Pollut E, Fuyang, Anhui, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2019年 / 14卷 / 04期

关键词：

anticancer drug; methotrexate; graphite oxide-Nafion; determination; ELECTROCHEMICAL OXIDATION FLUOROMETRY; STRIPPING VOLTAMMETRIC DETERMINATION; HIGH-DOSE METHOTREXATE; FOLIC-ACID; SENSOR; CHROMATOGRAPHY; ADSORPTION; THERAPY; EPIRUBICIN; NANOTUBES;

D O I：

10.20964/2019.04.03

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

In this paper, a graphite oxide-Nafion-glassy carbon electrode (GO-Nafion-GCE) by coating method was fabricated and used for study the electrochemical behavior and measurement of methotrexate (MTX) by cycle voltammetry (CV). The influence factors, such as volume of modifier, type of supporting electrolyte, concentration of electrolyte, scan rate, preconcentration time, and preconcentration potential on the anodic peak current of MTX were examined. The experimental results indicated that the electrode process is an adsorption-diffusion mixed controlled process. Under the experimental conditions of research, the anodic peak current of MTX shows a linear relationship within concentration range of 4.0 x 10(-7). 2.0 x 10(-5) mol L-1. The linear relationship can be expressed with the equation of I-p,I-a(mu A) = (0.4739 +/- 0.0086) C(mu M) + (0.2885 +/- 0.0434). Under the optimum electrochemical experimental conditions, the limit of detection (LOD) can be calculated to be 9.0 x 10(-9) mol L-1 (S/N=3). The proposed method has been used for the detection of MTX in methotrexate injection and urine samples successfully.

引用

页码：3792 / 3804

页数：13

共 54 条

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