Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate

被引:15
作者
Choi, Yeon Ja [1 ,2 ]
Kim, Dae Hyun [1 ,2 ]
Lee, Eun Kyeong [1 ,5 ]
Kim, Ji Min [1 ]
Ha, Young Mi [1 ,2 ]
Kim, Nam Deuk [1 ,2 ]
Jung, Jee H. [1 ,2 ]
Choi, Jae Sue [3 ]
Yu, Byung Pal [4 ]
Chung, Hae Young [1 ,2 ]
机构
[1] Pusan Natl Univ, Dept Pharm, Coll Pharm, Pusan 609735, South Korea
[2] Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent MRCA, Pusan 609735, South Korea
[3] Pukyong Natl Univ, Fac Food Sci & Biotechnol, Pusan 608737, South Korea
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA
[5] Dongnam Inst Radiol & Med Sci, Res Ctr, Pusan 619953, South Korea
基金
新加坡国家研究基金会;
关键词
Ferulate; FOXO3a; Aging; PI3K/Akt; MnSOD; Catalase; PROTEIN-KINASE B; NF-KAPPA-B; TRANSCRIPTION FACTORS; ANTIOXIDANT ENZYMES; OXIDATIVE STRESS; SODIUM FERULATE; ACID; INSULIN; AKT; EXPRESSION;
D O I
10.1007/s11357-011-9235-3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Ferulate (4-hydroxy-3-methoxycinnamic acid) is a well-known phenolic compound that scavenges free radicals and exerts anti-inflammatory effects. Forkhead box O3a (FOXO3a), a transcription factor that plays important roles in aging processes, decreases with age and is negatively regulated through phosphorylation by phosphatidylinositol 3-kinase (PI3K)/Akt signaling. The present study investigated the efficacy of short-term ferulate feeding on age-related changes in PI3K/Akt/FOXO3a and upstream insulin signaling pathways in aged rats. In addition, changes in manganese superoxide dismutase (MnSOD) and catalase expression were examined because of their dependence on PI3K/Akt/FOXO3a activity. Short-term feeding experiments were done with a diet containing ferulate that was given to aged rats at doses of 3 or 6 mg kg(-1) day(-1) for 10 days. Results showed that FOXO3a activity was increased in the ferulate-fed old group compared with the control old group. Also, ferulate suppressed the PI3K/Akt signaling pathway that is responsible for FOXO3a inhibition in aged rats. Plasma insulin levels and the upstream insulin signaling pathway were also modulated by ferulate correspondingly with PI3K/Akt/FOXO3a activity. The age-related decrease in two major antioxidant enzymes, MnSOD and catalase, was blunted by ferulate, which was accompanied by FOXO3a transcriptional activity. The significance of the present study is the finding that short-term feeding of ferulate effectively modulates age-related renal FOXO3a, PI3K/Akt and insulin signaling pathways, and MnSOD and catalase expression, all of which may be beneficial for attenuating the aging process.
引用
收藏
页码:317 / 327
页数:11
相关论文
共 47 条
  • [1] Mechanism of activation of protein kinase B by insulin and IGF-1
    Alessi, DR
    Andjelkovic, M
    Caudwell, B
    Cron, P
    Morrice, N
    Cohen, P
    Hemmings, BA
    [J]. EMBO JOURNAL, 1996, 15 (23) : 6541 - 6551
  • [2] Ferulic acid and its therapeutic potential as a hormetin for age-related diseases
    Barone, Eugenio
    Calabrese, Vittorio
    Mancuso, Cesare
    [J]. BIOGERONTOLOGY, 2009, 10 (02) : 97 - 108
  • [3] Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor α expression reversing invasive phenotype of breast cancer cells
    Belguise, Karine
    Guo, Shangqin
    Sonenshein, Gail E.
    [J]. CANCER RESEARCH, 2007, 67 (12) : 5763 - 5770
  • [4] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    Brunet, A
    Bonni, A
    Zigmond, MJ
    Lin, MZ
    Juo, P
    Hu, LS
    Anderson, MJ
    Arden, KC
    Blenis, J
    Greenberg, ME
    [J]. CELL, 1999, 96 (06) : 857 - 868
  • [5] Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells
    Chang, C. J.
    Chiu, J. H.
    Tseng, L. M.
    Chang, C. H.
    Chien, T. M.
    Wu, C. W.
    Lui, W. Y.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2006, 36 (08) : 588 - 596
  • [6] Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    Coschigano, KT
    Holland, AN
    Riders, ME
    List, EO
    Flyvbjerg, A
    Kopchick, JJ
    [J]. ENDOCRINOLOGY, 2003, 144 (09) : 3799 - 3810
  • [7] Trastuzumab-resistant HER2-Driven breast cancer cells are sensitive to epigallocatechin-3 gallate
    Eddy, Sean F.
    Kane, Susan E.
    Sonenshein, Gail E.
    [J]. CANCER RESEARCH, 2007, 67 (19) : 9018 - 9023
  • [8] Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    Fang, Jing
    Zhou, Qiong
    Shi, Xiang-lin
    Jiang, Bing-hua
    [J]. CARCINOGENESIS, 2007, 28 (03) : 713 - 723
  • [9] Gems D, 1998, GENETICS, V150, P129
  • [10] ANTIOXIDANT POTENTIAL OF FERULIC ACID
    GRAF, E
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) : 435 - 448