Peroxiredoxin sets the brain on fire after stroke

被引：43

作者：

Garcia-Bonilla, Lidia ^{[1
]}

Iadecola, Costantino ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Neurol & Neurosci, Div Neurobiol, New York, NY USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 06期

关键词：

POSTISCHEMIC INFLAMMATION; PIVOTAL ROLE; INJURY; MECHANISMS; RECEPTORS; DAMAGE;

D O I：

10.1038/nm.2797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How blood-borne inflammatory cells cause tissue damage in the brain after ischemic stroke remains elusive. Peroxiredoxins, cytosolic antioxidant proteins vital for redox balance, are released extracellularly from ischemic cells, acting as potent 'danger signals' that activate macrophages and lead to a harmful cytokine response, a new study shows. The findings unveil a new culprit in the delayed phase of ischemic injury and suggest new therapeutic approaches (pages 911-917).

引用

页码：858 / 859

页数：2

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