New routes for the synthesis of fused pyrrole scaffolds through transition metal-free tandem reactions

被引：16

作者：

Yang, Bingchuan ^{[1
]}

Huang, Zixiao ^{[1
]}

Guan, Hegen ^{[1
]}

Niu, Xiaoyi ^{[1
]}

Li, Yanqiu ^{[1
]}

Fang, Shuai ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 45期

基金：

美国国家科学基金会;

关键词：

Indolizine; One-pot; Pyrrole; Tandem reaction; Transition metal-free; POT REGIOSELECTIVE SYNTHESIS; SMILES REARRANGEMENT; INDOLIZINE DERIVATIVES; INHIBITORS; SWAINSONINE; BLOCKERS; BEHAVIOR; ANALOGS;

D O I：

10.1016/j.tetlet.2013.08.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of transition metal-free tandem reactions for the synthesis of indolizines and 6,7-dihydroindolizin-8(5H)-ones by 4-bromobut-2-enoate ramifications reacted with 2-acetyl pyrrole derivatives are described. As the alpha-carbon changed from CH3, CH2Cl, CHCl2, to CCl3, different kinds of tandem reactions were observed. These tandem reactions could be used to synthesize fused indolizine and indolizidine scaffolds under mild and green conditions. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5994 / 5997

页数：4

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