Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells

被引：67

作者：

Hou, Rong-Rong ^{[1
]}

Chen, Jian-Zong ^{[1
]}

Chen, Hong ^{[1
]}

Kang, Xiao-Gang ^{[1
]}

Li, Min-Ge ^{[2
]}

Wang, Bai-Ren ^{[3
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Lab Integrated Tradit Chinese Med & Western Med E, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Coll Stomatol, Tissue Engn Ctr, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Shaanxi, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2008年 / 32卷 / 01期

关键词：

(-)-Epigallocatechin-3-gallate; PC12; cells; Paraquat; Apoptosis; Neuroprotection; Parkinson's disease;

D O I：

10.1016/j.cellbi.2007.08.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Green tea, owing to its beneficial effect on health, is becoming more and more popular worldwide. (-)-Epigallocatechin-3-gallate (EGCG), the main ingredient of green tea polyphenols, is a known protective effect on injured neurons in neurodegenerative disease, such as Alzheimer's disease and Parkinson's disease. Paraquat (PQ) is a widely used herbicide that possesses a similar structure to MPP+ and is toxic to mesencephalic dopaminergic neurons. In the present study, PQ-injured PC12 cells were chosen as an in vitro cell model of Parkinson's disease and the neuroprotective effects of EGCG were investigated. The results showed that EGCG attenuated apoptosis of PC12 cells induced by PQ. The possible mechanism may be associated with maintaining mitochondrial membrane potential, inhibiting caspase-3 activity and downregulating the expression of pro-apoptotic protein Smac in cytosol. The present study supports the notion that EGCG could be used as a neuroprotective agent for treatment of neurodegenerative diseases. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：22 / 30

页数：9

共 35 条

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