Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells

被引：170

作者：

Jacobs, Sandra A. ^{[1
]}

Roobrouck, Valerie D. ^{[2
]}

Verfaillie, Catherine M. ^{[2
]}

Van Gool, Stefaan W. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Pediat Immunol, Dept Microbiol & Immunol, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Stem Cell Inst Leuven, Dept Dev & Regenerat, B-3000 Louvain, Belgium

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2013年 / 91卷 / 01期

关键词：

multipotent adult progenitor cells; mesenchymal stem cells; phenotype; immunomodulation; VERSUS-HOST-DISEASE; MARROW STROMAL CELLS; SUPPRESS T-LYMPHOCYTE; HUMAN ADIPOSE-TISSUE; BONE-MARROW; IN-VITRO; PEDIATRIC-PATIENTS; INHIBIT; DIFFERENTIATION; THERAPY;

D O I：

10.1038/icb.2012.64

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Somatic, also termed adult, stem cells are highly attractive biomedical cell candidates because of their extensive replication potential and functional multilineage differentiation capacity. They can be used for drug and toxicity screenings in preclinical studies, as in vitro model to study differentiation or for regenerative medicine to aid in the repair of tissues or replace tissues that are lost upon disease, injury or ageing. Multipotent adult progenitor cells (MAPCs) and mesenchymal stem cells (MSCs) are two types of adult stem cells derived from bone marrow that are currently being used clinically for tissue regeneration and for their immunomodulatory and trophic effects. This review will give an overview of the phenotypic and functional differences between human MAPCs and MSCs, with a strong emphasis on their immunological characteristics. Finally, we will discuss the clinical studies in which MSCs and MAPCs are already used. Immunology and Cell Biology (2013) 91, 32-39; doi:10.1038/icb.2012.64

引用

页码：32 / 39

页数：8

共 102 条

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