Vitamin D in sepsis: from basic science to clinical impact

被引：51

作者：

Kempker, Jordan A. ^{[1
]}

Tangpricha, Vin ^{[2
]}

Ziegler, Thomas R. ^{[3
]}

Martin, Greg S. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Div Pulm & Crit Care Med, Atlanta, GA 30303 USA

[2] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30023 USA

来源：

CRITICAL CARE | 2012年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

SERUM 25-HYDROXYVITAMIN D; RESPIRATORY-TRACT INFECTION; D DEFICIENCY; SEASONAL-VARIATION; D SUPPLEMENTATION; CYTOKINE PRODUCTION; MORTALITY; RISK; CARE; EPIDEMIOLOGY;

D O I：

10.1186/cc11252

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The growing basic and clinical investigations into the extraskeletal effects of vitamin D have revealed roles in the functioning of the immune system, generating interesting questions about this nutrient's connections to sepsis. This article briefly reviews the current science of the function of vitamin D in the immune system as well as the emerging clinical literature regarding its associations with respiratory infections, sepsis, and critical illness. Finally, we offer views on the potential future directions for research in the field by outlining potential relevant scenarios and outcomes.

引用

页数：6

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