Genetic Testing by Cancer Site Uterus

被引：18

作者：

Daniels, Molly S. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, Dept Gynecol Oncol & Reprod Med, Houston, TX 77230 USA

来源：

CANCER JOURNAL | 2012年 / 18卷 / 04期

关键词：

Lynch syndrome; hereditary nonpolyposis colorectal cancer; PTEN hamartoma; tumor syndrome; Cowden syndrome; hereditary leiomyomatosis and renal cell cancer; NONPOLYPOSIS COLORECTAL-CANCER; RENAL-CELL CANCER; FUMARATE HYDRATASE MUTATIONS; AUTISM SPECTRUM DISORDERS; GERMLINE PTEN MUTATIONS; DNA MISMATCH REPAIR; LYNCH-SYNDROME; ENDOMETRIAL CANCER; HEREDITARY LEIOMYOMATOSIS; COWDEN-SYNDROME;

D O I：

10.1097/PPO.0b013e3182610cc2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review article discusses hereditary cancer predisposition syndromes with uterine manifestations. Lynch syndrome accounts for 2% to 3% of endometrial cancers. The identification of endometrial cancer patients at risk for Lynch syndrome is discussed, as are the characteristics of Lynch syndrome-associated endometrial cancer and the screening and prevention options for women at risk for Lynch syndrome-associated endometrial cancer. Endometrial cancer associated with PTEN hamartoma tumor syndrome (also known as Cowden syndrome) is also discussed. HLRCC (hereditary leiomyomatosis and renal cell carcinoma), which has an associated high risk of symptomatic uterine leiomyomas, is reviewed.

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收藏

页码：338 / 342

页数：5

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