Neutrophils in the lung: "the first responders"

被引:70
作者
Aulakh, Gurpreet Kaur [1 ]
机构
[1] Univ Saskatchewan, Western Coll Vet Med, Small Anim Clin Sci, 52 Campus Dr, Saskatoon, SK S7N 5B4, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
Neutrophil; Lung; Angiostatin; Vitronectin; Synchrotron imaging; Intravital microscopy; PLASMINOGEN-ACTIVATOR INHIBITOR-1; RECEPTOR-MEDIATED ENDOCYTOSIS; TOLL-LIKE RECEPTORS; ENDOTHELIAL-CELLS; LEUKOCYTE EXTRAVASATION; EXTRACELLULAR TRAPS; BINDING-SITES; IN-VIVO; VITRONECTIN; ANGIOSTATIN;
D O I
10.1007/s00441-017-2748-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Neutrophils, constituting the first line of defense, perform vital functions during immune surveillance. A key feature that assists in their prompt response to an inflammatory signal is rapid migration to the affected site. They are normally short-lived but can be activated to live longer under the influence of an inflammatory stimulus. They can, thereby, release their toxic granule contents that are differentially housed inside the cytoplasm. Although these events are well characterized in the peripheral circulation, we are still far from fully understanding their recruitment in lungs. Lungs are a reservoir of neutrophils under steady-state. In the event of an infection or injury, they promptly activate and recruit to the alveolar compartment as well as the airways. Lung intravital microscopy has revealed that neutrophils display novel features during steady- and activated-state highlighting key differences in the lung vasculature compared to peripheral sites. This review will discuss neutrophil biology in lung inflammation and will highlight the role of angiostatin, an anti-angiogenic molecule, as well as vitronectin, an acute phase secreted plasma protein, in lung neutrophil recruitment.
引用
收藏
页码:577 / 588
页数:12
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