Arterial spin labeling perfusion magnetic resonance imaging of non-human primates

被引：6
作者：
Zhang, Xiaodong [1 ,2 ]
Li, Chun-Xia [1 ]
机构：
[1] Emory Univ, Yerkes Natl Primate Res Ctr, Yerkes Imaging Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA
[2] Emory Univ, Yerkes Natl Primate Res Ctr, Div Neuropharmacol & Neurol Dis, 954 Gatewood Rd NE, Atlanta, GA 30329 USA
来源：
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2016年 / 6卷 / 05期
关键词：
Continuous arterial spin labeling (CASL); pseudo-continuous arterial spin labeling (pCASL); macaque monkey; cerebral blood flow (CBF); clinical scanner; CEREBRAL-BLOOD-FLOW; TRANSIT-TIME; FUNCTIONAL MRI; MULTISLICE PERFUSION; OXYGEN-CONSUMPTION; BRAIN ACTIVATION; FMRI; INVERSION; MODEL; CBF;
D O I：
10.21037/qims.2016.10.05
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Non-human primates (NHPs) resemble most aspects of humans in brain physiology and anatomy and are excellent animal models for translational research in neuroscience, biomedical research and pharmaceutical development. Cerebral blood flow (CBF) offers essential physiological information of the brain to examine the abnormal functionality in NHP models with cerebral vascular diseases and neurological disorders or dementia. Arterial spin labeling (ASL) perfusion MRI techniques allow for high temporal and spatial CBF measurement and are intensively used in studies of animals and humans. In this article, current high-resolution ASL perfusion MRI techniques for quantitative evaluation of brain physiology and function in NHPs are described and their applications and limitation are discussed as well.
引用
收藏
页码：573 / 581
页数：9
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