Prognostic value of dual-time-point 18F-FDG PET-CT imaging in patients with head and neck squamous cell carcinoma

被引:25
作者
Abgral, Ronan [1 ]
Le Roux, Pierre-Yves [1 ]
Rousset, Jean [4 ]
Querellou, Solene [1 ]
Valette, Gerald [2 ]
Nowak, Emmanuel [3 ]
Turzo, Alexandre [1 ]
Tissot, Valentin [1 ]
Marianowski, Remi [2 ]
Salauen, Pierre-Yves [1 ]
机构
[1] Univ Hosp Brest, Dept Nucl Med, F-29200 Brest, France
[2] Univ Hosp Brest, Dept Head & Neck Surg, F-29200 Brest, France
[3] Univ Hosp Brest, INSERM 0502, Clin Invest Ctr, F-29200 Brest, France
[4] Mil Hosp Brest, Dept Radiol, Brest, France
关键词
F-18-fluorodeoxyglucose; dual-time-point imaging; head and neck squamous cell carcinoma; PET; prognosis; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; HEXOKINASE-II; CANCER; RECURRENCE; ACCUMULATION; RADIOTHERAPY; EXPRESSION;
D O I
10.1097/MNM.0b013e32836089ab
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective The objective of this study was to investigate the independent prognostic value of dual-time-point F-18-fluorodeoxyglucose (F-18-FDG) PET-CT imaging in patients with head and neck squamous cell carcinoma (HNSCC). Methods Patients referred to our department to undergo F-18-FDG PET-CT for staging of HNSCC were prospectively included. Each patient was scanned using a Philips Gemini PET-CT system 1 h (early acquisition) and 2 h (delayed acquisition) after injection. An intratumoral retention index (RI) of F-18-FDG was measured for each examination by the dual-time-point method. Event-free survival (EFS) and overall survival (OS) were determined by the Kaplan-Meier method and compared with the conventional maximum standardized uptake value (SUVmax) at 60 min, SUVmax at 120 min, and RI in univariate and multivariate analyses including the usual prognostic factors such as age, sex, primary site, SCC histologic grade, and American Joint Committee on Cancer stage (I, II, III, and IV). Results Sixty-six consecutive patients (60 men and six women; mean age = 61 +/- 9 years) were included in the study. In univariate analysis, besides age and stage, RI was predictive of EFS (P = 0.01) but not of OS (P = 0.1), whereas SUVmax at 60 min was not predictive of EFS (P = 0.18) or OS (P = 0.08) and SUVmax at 120 min was predictive of OS (P = 0.02) but not of EFS (P = 0.05). In multivariate analysis, RI persisted as an independent predictive factor for EFS (P = 0.02) but not SUVmax at 120 min for OS (P = 0.12). Conclusion Our results suggest an additional prognostic interest of RI measured by dual-time-point F-18-FDG PET-CT, independent of usual prognostic factors, in patients with HNSCC. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:551 / 556
页数:6
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