Metal-Free Decarboxylation of Alkynoic Acids for the Synthesis of Terminal Alkynes

被引：5

作者：

Seo, Eunkyeong ^{[1
]}

Oh, Jonghoon ^{[1
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

decarboxylation; terminal alkyne; alkynoic aicd; deuteration; metal-free conditions; ONE-POT CONVERSION; CARBOXYLIC-ACIDS; ALKYNYLATION; HALIDES;

D O I：

10.1002/ajoc.202000363

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Terminal alkynes were readily obtained via the reaction of alkynoic acids withN,N,N',N'-teramethylethylenediamine (TMEDA) in DMSO at 65 degrees C for 12 h. This method gave good yields and showed high functional group tolerance. In addition, deuterated terminal alkynes were formed in good yields when alkynoic acids were treated with D2O prior to the reaction with TMEDA.

引用

页码：1774 / 1777

页数：4

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