Coupling of Flow Techniques with Capillary Electrophoresis: Review of Operation Principles, Challenges, Potentials, and Applications

In this review, an overview is given of the up-to-date accomplished analytical systems combining flow techniques and capillary electrophoresis with the main focus on interfacing principles, challenges, potentials, and the resulting operation versatility as well as the incorporation of automated sample treatment prior to the electrophoretic separation. The up-to-date reported coupled systems are classified in tabular form in respect to interface types and analytical applications. An introduction into the different flow techniques and capillary electrophoresis is given further. In consequence, this review is aimed to complement former review articles, whose main focuses were analytical performance of the reviewed systems.