GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

被引：41
|
作者：
Arai, Sawako [2 ]
Takuma, Kazuhiro [2 ]
Mizoguchi, Hiroyuki [2 ,3 ]
Ibi, Daisuke [2 ]
Nagai, Taku [1 ]
Kamei, Hiroyuki [4 ]
Kim, Hyoung-Chun [5 ]
Yamada, Kiyofumi [1 ,2 ,6 ]
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668560, Japan
[2] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Life Sci, Lab Neuropsychopharmacol, Kanazawa, Ishikawa 9201192, Japan
[3] Nagoya Univ, Environm Med Res Inst, Futurist Environm Simulat Ctr, Nagoya, Aichi 4648601, Japan
[4] Meijo Univ, Grad Sch Pharmaceut Sci, Fac Pharm, Lab Clin Pharm Practice & Hlth Care Management, Nagoya, Aichi 4688503, Japan
[5] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea
[6] JST, CREST, Nagoya, Aichi 4668560, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 602卷 / 01期
关键词：
Baclofen; Cognitive deficit; Methamphetamine; Schizophrenia; VENTRAL TEGMENTAL AREA; RECOGNITION MEMORY; NUCLEUS-ACCUMBENS; DOPAMINE NEURONS; WORKING-MEMORY; SCHIZOPHRENIA; IMPAIRMENT; AMPHETAMINE; SENSITIZATION; CLOZAPINE;
D O I：
10.1016/j.ejphar.2008.10.065
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, we investigated the effects of GABA(A) and GABA(B) receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABA(B) receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABA(A) receptor agonist, had no significant effect. GABA(B) receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：101 / 104
页数：4
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