Reversed phase free ion selective radiotracer extraction (RP-FISRE): A new tool to assess the dynamic stabilities of metal (-organic) complexes, for complex half-lives spanning six orders of magnitude

被引：4

作者：

van der Meer, Astrid ^{[1
]}

Breeman, Wouter A. P. ^{[2
]}

Wolterbeek, Bert ^{[1
]}

机构：

[1] Delft Univ Technol TUDelft, NL-2629 JB Delft, Netherlands

[2] Erasmus MC, NL-3000 CA Rotterdam, Netherlands

来源：

APPLIED RADIATION AND ISOTOPES | 2013年 / 82卷

关键词：

Stability; Kinetics; Metal (-organic) complexes; DOTA; Octreotate; Lu-177; POLYAZA POLYCARBOXYLATE LIGANDS; LANTHANIDE COMPLEXES; LUMINESCENCE SPECTROSCOPY; DISSOCIATION KINETICS; EU(III) COMPLEXES; ACID; DOTA; GADOLINIUM; LU-177; EQUILIBRIUM;

D O I：

10.1016/j.apradiso.2013.06.021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper introduces reversed phase free ion selective radiotracer extraction (RP-FISRE) as a new tool to assess the stability of metal complexes, as illustrated by the assessment of the stability of [Lu-177]Lu-DOTA-octreotate. To this end, the TUDelft-developed FISRE, where the released metal is column-retained and the complex eluted, was changed into RP-FISRE, where the complex is column-retained and the released metal is eluted. This change in the approach allows for studies to be performed with high stability complexes. This paper presents RP-FISRE, the strength of the radiotracer approach, and the first-ever k(d) data on the release of Lu-177 from [Lu-177]Lu-DOTA-octreotate. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：28 / 35

页数：8

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