GUT MICROBIOTA IN 2012 Toward understanding and manipulating the gut microbiota

被引:23
作者
Aitken, Jesse D. [1 ]
Gewirtz, Andrew T. [1 ]
机构
[1] Georgia State Univ, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
关键词
INFLAMMATION; MICE;
D O I
10.1038/nrgastro.2012.252
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
New techniques have introduced unprecedented sensitivity to the investigation of the gut microbiota, enabling insights into the discrete contributions of select bacterial species and advancing our mechanistic appreciation of the roles of diet and host immunity in limiting or enabling metabolic and inflammatory disease. Aitken, J. D. & Gewirtz, A. T. Nat. Rev. Gastroenterol Hepatol. 10, 72-74 (2013); published online 8 January 2013; doi:10.1038/nrgastro.2012.252
引用
收藏
页码:72 / 74
页数:3
相关论文
共 9 条
[1]   Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].
Arthur, Janelle C. ;
Perez-Chanona, Ernesto ;
Muehlbauer, Marcus ;
Tomkovich, Sarah ;
Uronis, Joshua M. ;
Fan, Ting-Jia ;
Campbell, Barry J. ;
Abujamel, Turki ;
Dogan, Belgin ;
Rogers, Arlin B. ;
Rhodes, Jonathan M. ;
Stintzi, Alain ;
Simpson, Kenneth W. ;
Hansen, Jonathan J. ;
Keku, Temitope O. ;
Fodor, Anthony A. ;
Jobin, Christian .
SCIENCE, 2012, 338 (6103) :120-123
[2]   Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice [J].
Carvalho, Frederic A. ;
Koren, Omry ;
Goodrich, Julia K. ;
Johansson, Malin E. V. ;
Nalbantoglu, Ilke ;
Aitken, Jesse D. ;
Su, Yueju ;
Chassaing, Benoit ;
Walters, William A. ;
Gonzalez, Antonio ;
Clemente, Jose C. ;
Cullender, Tyler C. ;
Barnich, Nicolas ;
Darfeuille-Michaud, Arlette ;
Vijay-Kumar, Matam ;
Knight, Rob ;
Ley, Ruth E. ;
Gewirtz, Andrew T. .
CELL HOST & MICROBE, 2012, 12 (02) :139-152
[3]   Antibiotics in early life alter the murine colonic microbiome and adiposity [J].
Cho, Ilseung ;
Yamanishi, Shingo ;
Cox, Laura ;
Methe, Barbara A. ;
Zavadil, Jiri ;
Li, Kelvin ;
Gao, Zhan ;
Mahana, Douglas ;
Raju, Kartik ;
Teitler, Isabel ;
Li, Huilin ;
Alekseyenko, Alexander V. ;
Blaser, Martin J. .
NATURE, 2012, 488 (7413) :621-+
[4]   Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice [J].
Devkota, Suzanne ;
Wang, Yunwei ;
Musch, Mark W. ;
Leone, Vanessa ;
Fehlner-Peach, Hannah ;
Nadimpalli, Anuradha ;
Antonopoulos, Dionysios A. ;
Jabri, Bana ;
Chang, Eugene B. .
NATURE, 2012, 487 (7405) :104-+
[5]   ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation [J].
Hashimoto, Tatsuo ;
Perlot, Thomas ;
Rehman, Ateequr ;
Trichereau, Jean ;
Ishiguro, Hiroaki ;
Paolino, Magdalena ;
Sigl, Verena ;
Hanada, Toshikatsu ;
Hanada, Reiko ;
Lipinski, Simone ;
Wild, Birgit ;
Camargo, Simone M. R. ;
Singer, Dustin ;
Richter, Andreas ;
Kuba, Keiji ;
Fukamizu, Akiyoshi ;
Schreiber, Stefan ;
Clevers, Hans ;
Verrey, Francois ;
Rosenstiel, Philip ;
Penninger, Josef M. .
NATURE, 2012, 487 (7408) :477-U89
[6]   Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity [J].
Henao-Mejia, Jorge ;
Elinav, Eran ;
Jin, Chengcheng ;
Hao, Liming ;
Mehal, Wajahat Z. ;
Strowig, Till ;
Thaiss, Christoph A. ;
Kau, Andrew L. ;
Eisenbarth, Stephanie C. ;
Jurczak, Michael J. ;
Camporez, Joao-Paulo ;
Shulman, Gerald I. ;
Gordon, Jeffrey I. ;
Hoffman, Hal M. ;
Flavell, Richard A. .
NATURE, 2012, 482 (7384) :179-U67
[7]   Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy [J].
Koren, Omry ;
Goodrich, Julia K. ;
Cullender, Tyler C. ;
Spor, Ayme ;
Laitinen, Kirsi ;
Backhed, Helene Kling ;
Gonzalez, Antonio ;
Werner, Jeffrey J. ;
Angenent, Largus T. ;
Knight, Rob ;
Backhed, Fredrik ;
Isolauri, Erika ;
Salminen, Seppo ;
Ley, Ruth E. .
CELL, 2012, 150 (03) :470-480
[8]   Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut [J].
Shulzhenko, Natalia ;
Morgun, Andrey ;
Hsiao, William ;
Battle, Michele ;
Yao, Michael ;
Gavrilova, Oksana ;
Orandle, Marlene ;
Mayer, Lloyd ;
Macpherson, Andrew J. ;
McCoy, Kathy D. ;
Fraser-Liggett, Claire ;
Matzinger, Polly .
NATURE MEDICINE, 2011, 17 (12) :1585-U97
[9]   Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome [J].
Vrieze, Anne ;
Van Nood, Els ;
Holleman, Frits ;
Salojarvi, Jarkko ;
Kootte, Ruud S. ;
Bartelsman, Joep F. W. M. ;
Dallinga-Thie, Geesje M. ;
Ackermans, Mariette T. ;
Serlie, Mireille J. ;
Oozeer, Raish ;
Derrien, Muriel ;
Druesne, Anne ;
Vlieg, Johan E. T. Van Hylckama ;
Bloks, Vincent W. ;
Groen, Albert K. ;
Heilig, Hans G. H. J. ;
Zoetendal, Erwin G. ;
Stroes, Erik S. ;
de Vos, Willem M. ;
Hoekstra, Joost B. L. ;
Nieuwdorp, Max .
GASTROENTEROLOGY, 2012, 143 (04) :913-+