Analysis of spontaneous regeneration of olfactory structures with emphasis on myelination and re-innervation of cortical areas

被引：3

作者：

Fukushima, Nanae ^{[1
]}

Yokouchi, Kumiko ^{[1
]}

Sakamoto, Michio ^{[1
]}

Sekiguchi, Yasuyuki ^{[1
]}

Koike, Hiroki ^{[1
]}

Kawagishi, Kyutaro ^{[1
]}

Moriizumi, Tetsuji ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Anat, Matsumoto, Nagano 3908621, Japan

来源：

NEUROSCIENCE LETTERS | 2013年 / 537卷

基金：

日本学术振兴会;

关键词：

Central olfactory tract; Mitral cells; Neuronal tracing; Regenerated areas; Ectopic myelination; Neonatal rats; CENTRAL-NERVOUS-SYSTEM; PIRIFORM CORTEX; SPINAL-INJURY; POSTNATAL RAT; PLASTICITY; TRACT; CNS; PROJECTIONS; INHIBITION; EMERGENCE;

D O I：

10.1016/j.neulet.2013.01.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regeneration of the lateral olfactory tract (LOT) occurs spontaneously after transection in developing rats. In neonatally LOT-transected rats, we observed a newly formed myelinated tract near the rhinal sulcus. The aim of this study was to analyze the precise re-innervated cortical areas and to demonstrate ectopic LOT myelination in neonatally LOT-transected rats. Neonatal rats were subjected to unilateral LOT transection and simultaneous injection of a retrograde fluorescent tracer into the posterior olfactory cortex to evaluate the degree of transection. After 8 weeks, bilateral olfactory bulbs of the rats were subjected to multiple injections of an anterograde neuronal tracer to determine the extent of the regenerated fibers. In the completely LOT-transected rats, the regenerated fibers were distributed in the anterior olfactory cortices: the anterior olfactory nucleus, the olfactory tubercle, and the rostral part of the piriform cortex. Ectopic myelination of LOT was evident immediately below the rhinal sulcus in the completely and incompletely LOT-transected rats. We concluded that the regenerated bulbar fibers were confined to the regions of the anterior olfactory cortices and that ectopic myelination of the regenerated LOT occurred only at a specific site near the rhinal sulcus. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：35 / 39

页数：5

共 24 条

[1] TRANS-NEURONAL TRANSPORT OF PEROXIDASE-CONJUGATED WHEAT-GERM-AGGLUTININ (WGA-HRP) FROM THE OLFACTORY EPITHELIUM TO THE BRAIN OF THE ADULT-RAT [J].

BAKER, H ;

SPENCER, RF .

EXPERIMENTAL BRAIN RESEARCH, 1986, 63 (03) :461-473

[2] PLASTICITY OF THE CORTICOSPINAL TRACT FOLLOWING MIDTHORACIC SPINAL-INJURY IN THE POSTNATAL RAT [J].

BERNSTEIN, DR ;

STELZNER, DJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 1983, 221 (04) :382-400

[3] Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system [J].

Brinkmann, Bastian G. ;

Agarwal, Amit ;

Sereda, Michael W. ;

Garratt, Alistair N. ;

Mueller, Thomas ;

Wende, Hagen ;

Stassart, Ruth M. ;

Nawaz, Schanila ;

Humml, Christian ;

Velanac, Viktorija ;

Radyushkin, Konstantin ;

Goebbels, Sandra ;

Fischer, Tobias M. ;

Franklin, Robin J. ;

Lai, Cary ;

Ehrenreich, Hannelore ;

Birchmeier, Carmen ;

Schwab, Markus H. ;

Nave, Klaus Armin .

NEURON, 2008, 59 (04) :581-595

[4] The role of extracellular matrix in CNS regeneration [J].

Busch, Sarah A. ;

Silver, Jerry .

CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (01) :120-127

[5] CORTICOSPINAL TRACT PLASTICITY AND ASTROGLIAL REACTIVITY AFTER CERVICAL SPINAL-INJURY IN THE POSTNATAL RAT [J].

FIRKINS, SS ;

BATES, CA ;

STELZNER, DJ .

EXPERIMENTAL NEUROLOGY, 1993, 120 (01) :1-15

[6] The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system [J].

Galtrey, Clare M. ;

Fawcett, James W. .

BRAIN RESEARCH REVIEWS, 2007, 54 (01) :1-18

[7] Parallel-distributed processing in olfactory cortex: New insights from morphological and physiological analysis of neuronal circuitry [J].

Haberly, LB .

CHEMICAL SENSES, 2001, 26 (05) :551-576

[8] Aberrant retinal projections in congenitally deaf mice: How are phenotypic characteristics specified in development and evolution? [J].

Hunt, DL ;

King, B ;

Kahn, DM ;

Yamoah, EN ;

Shull, GE ;

Krubitzer, L .

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY, 2005, 287A (01) :1051-1066

[9] Massive cross-modal cortical plasticity and the emergence of a new cortical area in developmentally blind mammals [J].

Kahn, DM ;

Krubitzer, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :11429-11434

[10] Synaptic activity and the construction of cortical circuits [J].

Katz, LC ;

Shatz, CJ .

SCIENCE, 1996, 274 (5290) :1133-1138

← 1 2 3 →