The PI3 Kinase Signaling Pathway in Prostate Cancer

被引：0
|
作者：
Elfiky, Aymen A. [1 ]
Jiang, Zhenyang [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Lank Ctr Genitourinary Oncol, Boston, MA 02115 USA
来源：
CURRENT CANCER DRUG TARGETS | 2013年 / 13卷 / 02期
关键词：
Androgen receptor; mammalian target of rapamycin; phosphatidylinositol; 3-kinase; prostate cancer; PTEN; ANDROGEN RECEPTOR FUNCTION; PTEN GENOMIC DELETION; 4-PHOSPHATASE TYPE-II; TRANSCRIPTION FACTORS; TUMOR-SUPPRESSOR; HORMONAL-THERAPY; CELL-POPULATIONS; FISH ANALYSIS; MTOR COMPLEX; GENE FUSIONS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic implications of targeting it.
引用
收藏
页码：157 / 164
页数：8
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