Computational methods in drug discovery

被引:368
作者
Leelananda, Sumudu P. [1 ]
Lindert, Steffen [1 ]
机构
[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
关键词
ADME; computer-aided drug design; docking; free energy; high-throughput screening; LBDD; lead optimization; machine learning; pharmacophore; QSAR; SBDD; scoring; target flexibility; PROTEIN-STRUCTURE PREDICTION; ACCELERATED MOLECULAR-DYNAMICS; FREE-ENERGY CALCULATIONS; SUPPORT VECTOR MACHINES; FARNESYL DIPHOSPHATE SYNTHASE; EMPIRICAL SCORING FUNCTIONS; LIGAND-BINDING AFFINITIES; DE-NOVO; QUANTITATIVE STRUCTURE; RECEPTOR FLEXIBILITY;
D O I
10.3762/bjoc.12.267
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery projects. Additionally, increasing knowledge of biological structures, as well as increasing computer power have made it possible to use computational methods effectively in various phases of the drug discovery and development pipeline. The importance of in silico tools is greater than ever before and has advanced pharmaceutical research. Here we present an overview of computational methods used in different facets of drug discovery and highlight some of the recent successes. In this review, both structure-based and ligand-based drug discovery methods are discussed. Advances in virtual high-throughput screening, protein structure prediction methods, protein-ligand docking, pharmacophore modeling and QSAR techniques are reviewed.
引用
收藏
页码:2694 / 2718
页数:25
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