Reversing the course of the competitive adsorption between a phospholipid and albumin at an air-water interface

被引:6
|
作者
Phuc Nghia Nguyen [1 ]
Waton, Gilles [1 ]
Vandamme, Thierry [2 ]
Krafft, Marie Pierre [1 ]
机构
[1] Univ Strasbourg UPR 22, CNRS, ICS, F-67034 Strasbourg 2, France
[2] Univ Strasbourg, Lab Concept & Applicat Mol Bioact CNRS UMR 7199, F-67401 Illkirch Graffenstaden, France
关键词
BOVINE SERUM-ALBUMIN; AIR/WATER INTERFACE; PULMONARY SURFACTANT; LUNG SURFACTANTS; INACTIVATION; DIPALMITOYLPHOSPHATIDYLCHOLINE; MONOLAYERS; BEHAVIOR; BSA;
D O I
10.1039/c3sm51941d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
When bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) compete for occupation of an air-water interface, the protein rapidly colonizes the interface, effectively hindering the access of the phospholipid, a situation encountered in certain pulmonary conditions. We found that DPPC can totally and irreversibly displace BSA from the surface of a gas bubble when submitted to sustained sinusoidal oscillations at frequencies in the range of those encountered in respiration, and this without recourse to any additive.
引用
收藏
页码:9972 / 9976
页数:5
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