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Reversing the course of the competitive adsorption between a phospholipid and albumin at an air-water interface
被引:6
|作者:
Phuc Nghia Nguyen
[1
]
Waton, Gilles
[1
]
Vandamme, Thierry
[2
]
Krafft, Marie Pierre
[1
]
机构:
[1] Univ Strasbourg UPR 22, CNRS, ICS, F-67034 Strasbourg 2, France
[2] Univ Strasbourg, Lab Concept & Applicat Mol Bioact CNRS UMR 7199, F-67401 Illkirch Graffenstaden, France
来源:
关键词:
BOVINE SERUM-ALBUMIN;
AIR/WATER INTERFACE;
PULMONARY SURFACTANT;
LUNG SURFACTANTS;
INACTIVATION;
DIPALMITOYLPHOSPHATIDYLCHOLINE;
MONOLAYERS;
BEHAVIOR;
BSA;
D O I:
10.1039/c3sm51941d
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
When bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) compete for occupation of an air-water interface, the protein rapidly colonizes the interface, effectively hindering the access of the phospholipid, a situation encountered in certain pulmonary conditions. We found that DPPC can totally and irreversibly displace BSA from the surface of a gas bubble when submitted to sustained sinusoidal oscillations at frequencies in the range of those encountered in respiration, and this without recourse to any additive.
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页码:9972 / 9976
页数:5
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