A New Wave in Treatment of Vascular Occlusive Disease: Biodegradable Stents-Clinical Experience and Scientific Principles

被引：40

作者：

Brown, David A. ^{[1
]}

Lee, Edward W. ^{[1
]}

Loh, Christopher T. ^{[1
]}

Kee, Stephen T. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2009年 / 20卷 / 03期

关键词：

PORCINE CORONARY-ARTERIES; DRUG-ELUTING STENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SERIAL INTRAVASCULAR ULTRASOUND; INTERVENTIONAL THERMAL-INJURY; CONGENITAL HEART-DISEASE; ANGIOGRAPHIC FOLLOW-UP; L-LACTIDE STENT; GENE DELIVERY; IN-VIVO;

D O I：

10.1016/j.jvir.2008.11.007

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Stent-based therapies in percutaneous vascular intervention are associated with significant long-term complications related to in-stent restenosis. A growing body of literature demonstrates the feasibility of biodegradable materials for endovascular stents, which may, in theory, circumvent many of the immunologic and inflammatory response issues seen with long-term metallic stent failure in coronary and peripheral applications. This review describes the history of endovascular stents and the challenges encountered with metallic, drug-eluting, and biodegradable stents. A review of the basic engineering principles of biodegradable stents is provided, along with a discussion of the cellular mechanisms of restenosis.

引用

页码：315 / 324

页数：10

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[21] Anti-monocyte chemoattractant protein-1 monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries [J].