Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

被引：53

作者：

Urrea, Laura ^{[1
,2
,3
,4
]}

Segura-Feliu, Miriam ^{[1
,2
,3
,4
]}

Masuda-Suzukake, Masami ^{[5
]}

Hervera, Arnau ^{[1
,2
,3
,4
]}

Pedraz, Lucas ^{[6
]}

Garcia Aznar, Jose Manuel ^{[7
]}

Vila, Miquel ^{[8
,9
]}

Samitier, Josep ^{[10
,11
,12
]}

Torrents, Eduard ^{[6
]}

Ferrer, Isidro ^{[4
,13
,14
,15
]}

Gavin, Rosalina ^{[1
,2
,3
,4
]}

Hagesawa, Masato ^{[5
]}

Antonio del Rio, Jose ^{[1
,2
,3
,4
]}

机构：

[1] Inst Bioengn Catalonia IBEC, Mol & Cellular Neurobiotechnol, Parc Cient Barcelona,Baldiri Reixac 15-21, E-08028 Barcelona, Spain

[2] Univ Barcelona, Dept Cell Biol Physiol & Immunol, Barcelona, Spain

[3] Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain

[4] Univ Barcelona, Inst Neurosci, Barcelona, Spain

[5] Tokyo Metropolitan Inst Med Sci, Dept Dementia & Higher Brain Funct, Setagaya Ku, Tokyo 1568506, Japan

[6] Inst Bioengn Catalonia IBEC, Bacterial Infect Antimicrobial Therapies, Parc Cient Barcelona, Barcelona, Spain

[7] Univ Zaragoza, Dept Mech Engn, Aragon Inst Engn Res, Multiscale Mech & Biol Engn M2BE, Zaragoza, Spain

[8] Autonomous Univ Barcelona, Ctr Networked Biomed Res Neurodegenerat Dis, Vall dHebron Res Inst, Neurodegenerat Dis Res Grp, Barcelona, Spain

[9] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[10] Inst Bioengn Catalonia IBEC, Nanobioengn Grp, Parc Cient Barcelona, Barcelona, Spain

[11] Univ Barcelona, Dept Elect, Marti i Franques 1, E-08028 Barcelona, Spain

[12] Ctr Invest Biomed Red Bioingn Biomat & Nanomed, CIBER BBN, Madrid 28029, Spain

[13] IDIBELL Hosp Univ Bellvitge, Inst Neuropatol, Lhospitalet De Llobregat, Spain

[14] Univ Barcelona, Fac Med, Dept Patol & Terapeut Expt, Barcelona, Spain

[15] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain

来源：

MOLECULAR NEUROBIOLOGY | 2018年 / 55卷 / 03期

基金：

欧洲研究理事会;

关键词：

Synuclein; Amyloid spreading; Prnp; Microfluidic devices; AMYLOID-BETA OLIGOMERS; A-BETA; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; PRECURSOR PROTEIN; AXONAL-TRANSPORT; NEURAL-NETWORK; IN-VIVO; MICE; PRPC;

D O I：

10.1007/s12035-017-0451-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.

引用

页码：1847 / 1860

页数：14

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