A New Analogue of Locked Cyclohexane Nucleic Acids

被引：0

作者：

Sala, Michal ^{[1
]}

Dejmek, Milan

Prochazkova, Eliska

Hrebabecky, Hubert

Rybacek, Jiri

Dracinsky, Martin

Novak, Pavel

Rosenbergova, Sarka

Rosenberg, Ivan

Nencka, Radim

机构：

[1] Gilead Sci Inc, Prague 16610, Czech Republic

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 17期

关键词：

nucleosides; bicyclic compounds; oligonucleotides; carbocycles; medicinal chemistry; ANTIVIRAL ACTIVITY; RNASE-H; NUCLEOSIDES; CONFORMATION; INHIBITORS; VIRUS; OLIGONUCLEOTIDES; CENA; LNA;

D O I：

10.1055/s-0034-1380744

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report on a new analogue of locked cyclohexane nucleic acids that contains an adenine nucleobase at an alternative position and which resembles homo-DNA. The crucial locked carbocyclic nucleoside monomer was prepared with high enantioselectivity and was subsequently incorporated into a pair of modified oligonucleotides that were subjected to hybridization studies.

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收藏

页码：2654 / 2662

页数：9

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