A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells

被引：38
作者：
Xu, Jing [1 ,2 ,3 ]
Lu, Yang [1 ]
Qiu, Songbo [1 ]
Chen, Zhi-Nan [2 ,3 ]
Fan, Zhen [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Fourth Mil Med Univ, Dept Cell Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Natl Key Discipline Cell Biol, Cell Engn Res Ctr, State Key Lab Canc Biol, Xian 710032, Peoples R China
来源：
CANCER LETTERS | 2013年 / 335卷 / 02期
关键词：
EMMPRIN/CD147; Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; alpha-SMA; Cancer stroma; COLLAGENASE-STIMULATING FACTOR; AUTOCRINE MOTILITY FACTOR; SMOOTH MUSCLE ACTIN; MESENCHYMAL TRANSITION; E-CADHERIN; CD147; EXPRESSION; CARCINOMA; INVASION; HAB18G/CD147;
D O I：
10.1016/j.canlet.2013.02.054
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of alpha-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：380 / 386
页数：7
相关论文
共 48 条
[21]   HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection [J].
Li, Yu ;
Xu, Jing ;
Chen, Li ;
Zhong, Wei-De ;
Zhang, Zheng ;
Mi, Li ;
Zhang, Yang ;
Liao, Cheng-Gong ;
Bian, Hui-Jie ;
Jiang, Jian-Li ;
Yang, Xiang-Min ;
Li, Xiao-Yan ;
Fan, Chun-Mei ;
Zhu, Ping ;
Fu, Li ;
Chen, Zhi-Nan .
HISTOPATHOLOGY, 2009, 54 (06) :677-687
[22]   Coevolution of cancer and stromal cellular responses [J].
Littlepage, LE ;
Egeblad, M ;
Werb, Z .
CANCER CELL, 2005, 7 (06) :499-500
[23]   Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake [J].
Loeffler, Markus ;
Krueger, Joerg A. ;
Niethammer, Andreas G. ;
Reisfeld, Ralph A. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1955-1962
[24]   Tumour-stroma interaction:: cancer-associated fibroblasts as novel targets in anti-cancer therapy? [J].
Micke, P ;
Östman, A .
LUNG CANCER, 2004, 45 :S163-S175
[25]   Exploring the tumour environment:: cancer-associated fibroblasts as targets in cancer therapy [J].
Micke, P ;
Östman, A .
EXPERT OPINION ON THERAPEUTIC TARGETS, 2005, 9 (06) :1217-1233
[26]   A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera [J].
Moonsom, Seangdeun ;
Tayapiwatana, Chatchai ;
Wongkham, Sopit ;
Kongtawelert, Prachya ;
Kasinrerk, Watchara .
HYBRIDOMA, 2010, 29 (01) :45-52
[27]   Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression [J].
Nabeshima, Kazuki ;
Iwasaki, Hiroshi ;
Koga, Kaori ;
Hojo, Hironobu ;
Suzumiya, Junji ;
Kikuchi, Masahiro .
PATHOLOGY INTERNATIONAL, 2006, 56 (07) :359-367
[28]   Role of emmprin in endometrial cancer [J].
Nakamura, Keiichiro ;
Kodama, Junichi ;
Hongo, Atsushi ;
Hiramatsu, Yuji .
BMC CANCER, 2012, 12
[29]   Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion [J].
Orimo, A ;
Gupta, PB ;
Sgroi, DC ;
Arenzana-Seisdedos, F ;
Delaunay, T ;
Naeem, R ;
Carey, VJ ;
Richardson, AL ;
Weinberg, RA .
CELL, 2005, 121 (03) :335-348
[30]   Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer [J].
Pertega-Gomes, Nelma ;
Vizcaino, Jose R. ;
Miranda-Goncalves, Vera ;
Pinheiro, Celine ;
Silva, Joana ;
Pereira, Helena ;
Monteiro, Pedro ;
Henrique, Rui M. ;
Reis, Rui M. ;
Lopes, Carlos ;
Baltazar, Fatima .
BMC CANCER, 2011, 11
12345