A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells

被引：38
作者：
Xu, Jing [1 ,2 ,3 ]
Lu, Yang [1 ]
Qiu, Songbo [1 ]
Chen, Zhi-Nan [2 ,3 ]
Fan, Zhen [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Fourth Mil Med Univ, Dept Cell Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Natl Key Discipline Cell Biol, Cell Engn Res Ctr, State Key Lab Canc Biol, Xian 710032, Peoples R China
来源：
CANCER LETTERS | 2013年 / 335卷 / 02期
关键词：
EMMPRIN/CD147; Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; alpha-SMA; Cancer stroma; COLLAGENASE-STIMULATING FACTOR; AUTOCRINE MOTILITY FACTOR; SMOOTH MUSCLE ACTIN; MESENCHYMAL TRANSITION; E-CADHERIN; CD147; EXPRESSION; CARCINOMA; INVASION; HAB18G/CD147;
D O I：
10.1016/j.canlet.2013.02.054
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of alpha-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：380 / 386
页数：7
相关论文
共 48 条
[1]   Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder [J].
Bhagirath, Divya ;
Abrol, Nitin ;
Khan, Rehan ;
Sharma, Manoj ;
Seth, Amlesh ;
Sharma, Alpana .
CLINICA CHIMICA ACTA, 2012, 413 (19-20) :1641-1646
[2]  
BISWAS C, 1995, CANCER RES, V55, P434
[3]   Mammary Tumors Initiated by Constitutive Cdk2 Activation Contain an Invasive Basal-like Component [J].
Corsino, Patrick E. ;
Davis, Bradley J. ;
Norgaard, Peter H. ;
Parker, Nicole N. Teoh ;
Law, Mary ;
Dunn, William ;
Law, Brian K. .
NEOPLASIA, 2008, 10 (11) :1240-1252
[4]   PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment [J].
Crawford, Yongping ;
Kasman, Ian ;
Yu, Lanlan ;
Zhong, Cuiling ;
Wu, Xiumin ;
Modrusan, Zora ;
Kaminker, Josh ;
Ferrara, Napoleone .
CANCER CELL, 2009, 15 (01) :21-34
[5]   Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway [J].
Cui, Hong-Yong ;
Guo, Tao ;
Wang, Shi-Jie ;
Zhao, Pu ;
Dong, Zhi-Shou ;
Zhang, Yang ;
Jiang, Jian-Li ;
Chen, Zhi-Nan ;
Yu, Xiao-Ling .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 419 (03) :517-522
[6]   The Pancreas Cancer Microenvironment [J].
Feig, Christine ;
Gopinathan, Aarthi ;
Neesse, Albrecht ;
Chan, Derek S. ;
Cook, Natalie ;
Tuveson, David A. .
CLINICAL CANCER RESEARCH, 2012, 18 (16) :4266-4276
[7]   A NEW METHOD FOR EVALUATION OF URINARY AUTOCRINE MOTILITY FACTOR AND TUMOR-CELL COLLAGENASE STIMULATING FACTOR AS MARKERS FOR URINARY-TRACT CANCERS [J].
GUIRGUIS, R ;
JAVADPOUR, N ;
SHARAREH, S ;
BISWAS, C ;
ELAMIN, W ;
MANSUR, I ;
KIM, JS .
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1990, 32 (09) :846-853
[8]   Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements [J].
Hajra, KM ;
Ji, XD ;
Fearon, ER .
ONCOGENE, 1999, 18 (51) :7274-7279
[9]   Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells [J].
Han, Mingli ;
Liu, Manran ;
Wang, Yimeng ;
Mo, Zhiqiang ;
Bi, Xiaokai ;
Liu, Zhirong ;
Fan, Yuanming ;
Chen, Xin ;
Wu, Chengyi .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 363 (1-2) :427-436
[10]   Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment [J].
Hanahan, Douglas ;
Coussens, Lisa M. .
CANCER CELL, 2012, 21 (03) :309-322
12345