A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells

被引：36
作者：
Xu, Jing [1 ,2 ,3 ]
Lu, Yang [1 ]
Qiu, Songbo [1 ]
Chen, Zhi-Nan [2 ,3 ]
Fan, Zhen [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Fourth Mil Med Univ, Dept Cell Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Natl Key Discipline Cell Biol, Cell Engn Res Ctr, State Key Lab Canc Biol, Xian 710032, Peoples R China
来源：
CANCER LETTERS | 2013年 / 335卷 / 02期
关键词：
EMMPRIN/CD147; Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; alpha-SMA; Cancer stroma; COLLAGENASE-STIMULATING FACTOR; AUTOCRINE MOTILITY FACTOR; SMOOTH MUSCLE ACTIN; MESENCHYMAL TRANSITION; E-CADHERIN; CD147; EXPRESSION; CARCINOMA; INVASION; HAB18G/CD147;
D O I：
10.1016/j.canlet.2013.02.054
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of alpha-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：380 / 386
页数：7
相关论文
共 48 条
  • [1] Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder
    Bhagirath, Divya
    Abrol, Nitin
    Khan, Rehan
    Sharma, Manoj
    Seth, Amlesh
    Sharma, Alpana
    [J]. CLINICA CHIMICA ACTA, 2012, 413 (19-20) : 1641 - 1646
  • [2] BISWAS C, 1995, CANCER RES, V55, P434
  • [3] Mammary Tumors Initiated by Constitutive Cdk2 Activation Contain an Invasive Basal-like Component
    Corsino, Patrick E.
    Davis, Bradley J.
    Norgaard, Peter H.
    Parker, Nicole N. Teoh
    Law, Mary
    Dunn, William
    Law, Brian K.
    [J]. NEOPLASIA, 2008, 10 (11): : 1240 - 1252
  • [4] PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
    Crawford, Yongping
    Kasman, Ian
    Yu, Lanlan
    Zhong, Cuiling
    Wu, Xiumin
    Modrusan, Zora
    Kaminker, Josh
    Ferrara, Napoleone
    [J]. CANCER CELL, 2009, 15 (01) : 21 - 34
  • [5] Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway
    Cui, Hong-Yong
    Guo, Tao
    Wang, Shi-Jie
    Zhao, Pu
    Dong, Zhi-Shou
    Zhang, Yang
    Jiang, Jian-Li
    Chen, Zhi-Nan
    Yu, Xiao-Ling
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 419 (03) : 517 - 522
  • [6] The Pancreas Cancer Microenvironment
    Feig, Christine
    Gopinathan, Aarthi
    Neesse, Albrecht
    Chan, Derek S.
    Cook, Natalie
    Tuveson, David A.
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (16) : 4266 - 4276
  • [7] A NEW METHOD FOR EVALUATION OF URINARY AUTOCRINE MOTILITY FACTOR AND TUMOR-CELL COLLAGENASE STIMULATING FACTOR AS MARKERS FOR URINARY-TRACT CANCERS
    GUIRGUIS, R
    JAVADPOUR, N
    SHARAREH, S
    BISWAS, C
    ELAMIN, W
    MANSUR, I
    KIM, JS
    [J]. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1990, 32 (09) : 846 - 853
  • [8] Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements
    Hajra, KM
    Ji, XD
    Fearon, ER
    [J]. ONCOGENE, 1999, 18 (51) : 7274 - 7279
  • [9] Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells
    Han, Mingli
    Liu, Manran
    Wang, Yimeng
    Mo, Zhiqiang
    Bi, Xiaokai
    Liu, Zhirong
    Fan, Yuanming
    Chen, Xin
    Wu, Chengyi
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 363 (1-2) : 427 - 436
  • [10] Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
    Hanahan, Douglas
    Coussens, Lisa M.
    [J]. CANCER CELL, 2012, 21 (03) : 309 - 322
12345