Integrated electrochemical detection for lab on a chip analytical microsystems

被引：9

作者：

Pai, RS ^{[1
]}

Roussel, TJ ^{[1
]}

Crain, MM ^{[1
]}

Jackson, DJ ^{[1
]}

Conklin, JA ^{[1
]}

Baldwin, RP ^{[1
]}

Keynton, RS ^{[1
]}

Naber, JF ^{[1
]}

Walsh, KM ^{[1
]}

机构：

[1] Univ Louisville, Dept Elect Engn, Louisville, KY 40292 USA

来源：

FOURTEENTH BIENNIAL UNIVERSITY/GOVERNMENT/INDUSTRY MICROELECTRONICS SYMPOSIUM, PROCEEDINGS | 2001年

关键词：

D O I：

10.1109/UGIM.2001.960323

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The purpose of this study is to develop a portable capillary electrophoresis (CE) "lab-on-a-chip" device that is integrated with on-chip separation and electrochemical detection (ECD) electrodes. Platinum electrodes were photo-lithographically patterned on soda time glass substrates and 20-mum by 80-mum channels were constructed within a second soda lime glass substrate. To fully realize the portability offered by this microfabricated device, a handheld battery powered CE/ECD circuit was also developed. Experimental flow visualization and computer simulation studies were performed to investigate electrokinetic flow within the microfabricated capillaries. CE/ECD "lab-on-a-chip" devices were successfully fabricated. These devices produced identical electrochemical responses for dopamine and catechol with both the portable electronics and conventional bench top power supply and detection equipment. Finally, the computer simulation results were within 10% of the experimental flow visualization results for injection and separation of dichlorofluoroscein.

引用

页码：167 / 170

页数：4

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