Recent developments in isocyanide based multicomponent reactions in applied chemistry

被引：4177
作者：
Dömling, A [1 ]
机构：
[1] ABC Pharm, D-81243 Munich, Germany
来源：
CHEMICAL REVIEWS | 2006年 / 106卷 / 01期
关键词：
D O I：
10.1021/cr0505728
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multicomponent reactions (MCRs) are reactions where more than two starting materials react to form a product, incorporating all of the atoms of the educts. These reactions are classified according to the reaction mechanisms, the components involved, or their intrinsic variability. This paper discusses stereocontrol in MCRs, novel isocyanide based MCRs (IMCRs), applications of MCRs in drug discovery, MCRs in natural product synthesis, and miscellaneous applications of IMCRs.
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页码：17 / 89
页数：73
相关论文
共 324 条
[21]   A new strategy for the synthesis of cyclopeptides containing diaminoglutaric acid [J].
Bayer, T ;
Riemer, C ;
Kessler, H .
JOURNAL OF PEPTIDE SCIENCE, 2001, 7 (05) :250-261
[22]   Short and diverse route toward complex natural product-like macrocycles [J].
Beck, B ;
Larbig, G ;
Mejat, B ;
Magnin-Lachaux, M ;
Picard, A ;
Herdtweck, E ;
Dömling, A .
ORGANIC LETTERS, 2003, 5 (07) :1047-1050
[23]   A novel three-component butenolide synthesis [J].
Beck, B ;
Magnin-Lachaux, M ;
Herdtweck, E ;
Dömling, A .
ORGANIC LETTERS, 2001, 3 (18) :2875-2878
[24]   One-pot synthesis and biological evaluation of aspergillamides and analogues [J].
Beck, B ;
Hess, S ;
Dömling, A .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) :1701-1705
[25]   Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence [J].
Beck, B ;
Picard, A ;
Herdtweck, E ;
Dömling, A .
ORGANIC LETTERS, 2004, 6 (01) :39-42
[26]   Substituted 2-(cyanomethyl-amino)-acetamides by a novel three-component reaction [J].
Behnke, D ;
Taube, R ;
Illgen, K ;
Nerdinger, S ;
Herdtweck, E .
SYNLETT, 2004, (04) :688-692
[27]  
Bienaymé H, 2000, ACTUAL CHIMIQUE, P29
[28]  
Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO
[29]  
2-A
[30]   Multicomponent reactions .2. Stereoselective synthesis of 1(S)-camphor-2-cis-methylidene-isocyanide and its application in Passerini- and Ugi-reaction [J].
Bock, H ;
Ugi, I .
JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG, 1997, 339 (04) :385-389
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